6ZIB

CRYSTAL STRUCTURE OF RAT PEROXISOMAL MULTIFUNCTIONAL ENZYME TYPE-1 (RPMFE1) COMPLEXED WITH ACETOACETYL-COA AND NADH


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth AAA]3HCDHe6zibAAA2 A: alpha arraysX: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)T: 6-phosphogluconate dehydrogenase C-terminal domain-likeF: 3HCDHECOD (1.6)
A [auth AAA]3HCDH_Ne6zibAAA4 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: 3HCDH_NECOD (1.6)
A [auth AAA]ECH_1e6zibAAA1 A: a/b three-layered sandwichesX: ClpP/crotonase (From Topology)H: ClpP/crotonase (From Topology)T: ClpP/crotonaseF: ECH_1ECOD (1.6)
B [auth BBB]3HCDHe6zibBBB3 A: alpha arraysX: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)H: 6-phosphogluconate dehydrogenase C-terminal domain-like (From Topology)T: 6-phosphogluconate dehydrogenase C-terminal domain-likeF: 3HCDHECOD (1.6)
B [auth BBB]3HCDH_Ne6zibBBB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: 3HCDH_NECOD (1.6)
B [auth BBB]ECH_1e6zibBBB4 A: a/b three-layered sandwichesX: ClpP/crotonase (From Topology)H: ClpP/crotonase (From Topology)T: ClpP/crotonaseF: ECH_1ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth AAA],
B [auth BBB]
PF027373-hydroxyacyl-CoA dehydrogenase, NAD binding domain (3HCDH_N)3-hydroxyacyl-CoA dehydrogenase, NAD binding domainThis family also includes lambda crystallin.Domain
A [auth AAA],
B [auth BBB]
PF007253-hydroxyacyl-CoA dehydrogenase, C-terminal domain (3HCDH)3-hydroxyacyl-CoA dehydrogenase, C-terminal domainThis family also includes lambda crystallin. Some proteins include two copies of this domain.Domain
A [auth AAA],
B [auth BBB]
PF00378Enoyl-CoA hydratase/isomerase (ECH_1)Enoyl-CoA hydratase/isomeraseThis family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth AAA],
B [auth BBB]
Peroxisomal bifunctional enzyme