Annotations: 6ZPD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	CRAL/TRIO domain	8040349	3001058	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CRAL_TRIO_N	e6zpdA1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: CRAL_TRIO_N	ECOD (1.6)
A	CRAL_TRIO	e6zpdA2	A: a/b three-layered sandwiches	X: SpoIIaa-like (From Topology)	H: SpoIIaa-like (From Topology)	T: SpoIIaa-like	F: CRAL_TRIO	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00650	CRAL/TRIO domain (CRAL_TRIO)	CRAL/TRIO domain	-	Domain
A	PF03765	CRAL/TRIO, N-terminal domain (CRAL_TRIO_N)	CRAL/TRIO, N-terminal domain	This all-alpha domain is found to the N-terminus of Pfam:PF00650.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Alpha-tocopherol transfer protein	binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidylinositol-3,4-bisphosphate binding vitamin binding organic cyclic compound binding heterocyclic compound binding binding ion binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidylinositol-3,4-bisphosphate binding vitamin binding organic cyclic compound binding heterocyclic compound binding vitamin E binding lipid transporter activity lipid transfer activity transporter activity	localization transport vitamin transport establishment of localization vitamin E metabolic process fat-soluble vitamin metabolic process organic hydroxy compound metabolic process metabolic process small molecule metabolic process vitamin metabolic process membrane organization intermembrane lipid transfer lipid localization lipid transport localization transport vitamin transport establishment of localization vitamin E metabolic process fat-soluble vitamin metabolic process organic hydroxy compound metabolic process metabolic process small molecule metabolic process vitamin metabolic process membrane organization intermembrane lipid transfer lipid localization lipid transport cellular component organization macromolecule localization cellular process cellular component organization or biogenesis multicellular organismal process regulation of biological process biological regulation positive regulation of biological process positive regulation of amyloid-beta clearance positive regulation of multicellular organismal process regulation of multicellular organismal process amyloid-beta clearance regulation of amyloid-beta clearance primary metabolic process lipid metabolic process developmental process placenta development chordate embryonic development animal organ development embryo development in utero embryonic development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching anatomical structure development embryonic organ development regulation of cellular process regulation of developmental process cellular developmental process regulation of establishment of blood-brain barrier negative regulation of biological process cell development regulation of cell differentiation regulation of cell development cell differentiation negative regulation of cellular process negative regulation of cell differentiation system development establishment of blood-brain barrier negative regulation of developmental process nervous system development negative regulation of cell development central nervous system development negative regulation of establishment of blood-brain barrier response to stimulus response to chemical response to toxic substance	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle late endosome vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001251	CRAL-TRIO lipid binding domain	Domain
A	IPR036865	CRAL-TRIO lipid binding domain superfamily	Homologous Superfamily
A	IPR011074	CRAL/TRIO, N-terminal domain	Domain
A	IPR036273	CRAL/TRIO, N-terminal domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P49638	familial isolated deficiency of vitamin E retinitis pigmentosa muscular atrophy nervous system disorder speech disorder atherosclerosis Vitamin E Deficiency hearing disorder hyperreflexia retinal disease vision disorder lung cancer arteriosclerosis disorder cone-rod dystrophy pancreatic ductal adenocarcinoma familial isolated deficiency of vitamin E retinitis pigmentosa muscular atrophy nervous system disorder speech disorder atherosclerosis Vitamin E Deficiency hearing disorder hyperreflexia retinal disease vision disorder lung cancer arteriosclerosis disorder cone-rod dystrophy pancreatic ductal adenocarcinoma Charcot-Marie-Tooth disease intellectual disability malignant colon neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.