7A1S

FACTOR INHIBITING HIF-1 ALPHA IN COMPLEX WITH ZN(II), 3-methyl-2-oxoglutarate, AND TANKYRASE-2 (TNKS2) FRAGMENT PEPTIDE (21-MER)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Clavaminate synthase-like	8043914	3001848	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	JmjC_1	e7a1sA1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: JmjC_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13621	Cupin-like domain (Cupin_8)	Cupin-like domain	This cupin like domain shares similarity to the JmjC domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hypoxia-inducible factor 1-alpha inhibitor	transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding NF-kappaB binding cation binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding NF-kappaB binding cation binding transition metal ion binding iron ion binding ion binding ferrous iron binding metal ion binding small molecule binding identical protein binding protein homodimerization activity protein dimerization activity small molecule sensor activity oxygen sensor activity ankyrin repeat binding protein domain specific binding oxidoreductase activity catalytic activity, acting on a protein oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-aspartic acid 3-dioxygenase activity catalytic activity 2-oxoglutarate-dependent dioxygenase activity dioxygenase activity [protein]-asparagine 3-dioxygenase activity zinc ion binding organic acid binding anion binding carboxylic acid binding peptidyl-histidine dioxygenase activity	developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process biological regulation positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation cellular process myoblast differentiation positive regulation of cellular process multicellular organismal process regulation of vasculogenesis vasculogenesis multicellular organism development tube morphogenesis blood vessel development system development blood vessel morphogenesis tube development vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculogenesis cellular response to stimulus response to stimulus negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of cellular process signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol perinuclear region of cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen
B	TANKYRASE-2	NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding binding enzyme binding cation binding ion binding NAD+ ADP-ribosyltransferase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity catalytic activity, acting on a protein NAD+-protein ADP-ribosyltransferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups protein binding binding enzyme binding cation binding ion binding metal ion binding small molecule binding	organonitrogen compound metabolic process protein polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of organelle organization regulation of cellular process organonitrogen compound metabolic process protein polyubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal positive regulation of organelle organization regulation of cellular process telomere organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process cellular metabolic process regulation of cellular metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization telomere maintenance biosynthetic process positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase regulation of macromolecule biosynthetic process DNA biosynthetic process regulation of metabolic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process cellular component organization nucleic acid biosynthetic process positive regulation of biosynthetic process cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process telomere maintenance via telomerase biological regulation chromosome organization positive regulation of DNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process organelle organization cellular process positive regulation of cellular biosynthetic process protein localization localization cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to chromosome, telomeric region negative regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening negative regulation of biological process negative regulation of chromosome organization negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of cellular component organization negative regulation of metabolic process negative regulation of organelle organization negative regulation of DNA metabolic process cellular response to stimulus cell surface receptor signaling pathway response to stimulus signaling cell communication signal transduction Wnt signaling pathway positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling protein poly-ADP-ribosylation positive regulation of telomere capping telomere capping regulation of telomere capping protein auto-ADP-ribosylation	membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus cellular anatomical entity intracellular membrane-bounded organelle endomembrane system cytoplasm cytosol Golgi membrane Golgi apparatus membrane bounding membrane of organelle organelle membrane pericentriolar material centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle perinuclear region of cytoplasm chromosome chromosome, telomeric region chromosomal region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003347	JmjC domain	Domain
A	IPR027452	Hypoxia-inducible factor 1-alpha inhibitor, domain II	Homologous Superfamily
A	IPR014710	RmlC-like jelly roll fold	Homologous Superfamily
A	IPR041667	Cupin-like domain 8	Domain
B	IPR050745	Multifunctional regulatory proteins	Family
B	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
B	IPR012317	Poly(ADP-ribose) polymerase, catalytic domain	Domain
B	IPR002110	Ankyrin repeat	Repeat
B	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
B	IPR001660	Sterile alpha motif domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NWT6	diabetes mellitus ovarian cancer large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia osteosarcoma psoriasis
B	Pharos: Q9H2K2	ovarian cancer acute myeloid leukemia exocrine pancreatic carcinoma intellectual disability malignant glioma mast cell leukemia aggressive systemic mastocytosis Hormone refractory prostate cancer interstitial lung disease malignant pancreatic neoplasm medulloblastoma ovarian epithelial tumor atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.