Annotations: 7BI4

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00613	Phosphoinositide 3-kinase family, accessory domain (PIK domain) (PI3Ka)	Phosphoinositide 3-kinase family, accessory domain (PIK domain)	-	Repeat
A	PF00792	Phosphoinositide 3-kinase C2 (PI3K_C2)	Phosphoinositide 3-kinase C2	Phosphoinositide 3-kinase region postulated to contain a C2 domain. Outlier of Pfam:PF00168 family.	Domain
A	PF00794	PI3-kinase family, ras-binding domain (PI3K_rbd)	PI3-kinase family, ras-binding domain	Certain members of the PI3K family possess Ras-binding domains in their N-termini. These regions show some similarity (although not highly significant similarity) to Ras-binding Pfam:PF00788 domains (unpublished observation).	Domain
A	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha,Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	binding phospholipid binding lipid binding phosphatidylinositol binding clathrin binding protein binding phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding phospholipid binding lipid binding phosphatidylinositol binding clathrin binding protein binding phosphatidylinositol kinase activity kinase activity lipid kinase activity transferase activity 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups 1-phosphatidylinositol-3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process cellular biosynthetic process glycerophospholipid metabolic process lipid biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process phosphatidylinositol metabolic process glycerophospholipid biosynthetic process phosphatidylinositol-3-phosphate biosynthetic process cellular metabolic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process metabolic process cellular process glycerolipid metabolic process lipid metabolic process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction localization import into cell transport endocytosis establishment of localization vesicle-mediated transport cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to starvation phosphatidylinositol-mediated signaling cellular catabolic process catabolic process macroautophagy autophagy process utilizing autophagic mechanism regulation of localization negative regulation of zinc ion transport negative regulation of monoatomic ion transport monoatomic ion transmembrane transport negative regulation of biological process negative regulation of transport regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of zinc ion transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport negative regulation of cation transmembrane transport negative regulation of zinc ion transmembrane transport monoatomic cation transport regulation of metal ion transport regulation of transport regulation of monoatomic ion transport zinc ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of zinc ion transmembrane transport regulation of transmembrane transport zinc ion transmembrane transport transition metal ion transport regulation of monoatomic cation transmembrane transport secretion by cell exocytosis secretion export from cell vacuole organization autophagosome organization cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle clathrin-coated vesicle coated vesicle cytoplasm cell periphery plasma membrane membrane-bounded organelle organelle cellular anatomical entity vesicle intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle clathrin-coated vesicle coated vesicle cytoplasm cell periphery plasma membrane membrane Golgi apparatus subcompartment Golgi apparatus organelle subcompartment endomembrane system trans-Golgi network phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane protein complex transferase complex extrinsic component of membrane nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015433	Phosphatidylinositol kinase	Family
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR002420	C2 phosphatidylinositol 3-kinase-type domain	Domain
A	IPR001683	Phox homology	Domain
A	IPR000008	C2 domain	Domain
A	IPR042133	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain	Domain
A	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	Conserved Site
A	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	Domain
A	IPR042236	Phosphoinositide 3-kinase, accessory (PIK) domain superfamily	Homologous Superfamily
A	IPR036940	Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily	Homologous Superfamily
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR036871	PX domain superfamily	Homologous Superfamily
A	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR037705	PI3K-C2-alpha, catalytic domain	Domain
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.