7CCA
Crystal structure of White Spot Syndrome Virus Thymidylate Synthase - ternary complex with Methotrexate and dUMP
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d7ccaa_ | Alpha and beta proteins (a+b) | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | automated matches | WSSV (Shrimp white spot syndrome virus (isolate Tongan) ) [TaxId: 654913 ], | SCOPe (2.08) |
B | d7ccab_ | Alpha and beta proteins (a+b) | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | automated matches | WSSV (Shrimp white spot syndrome virus (isolate Tongan) ) [TaxId: 654913 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | Thymidylate synthase/dCMP hydroxymethylase | 8102197 | 4001903 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8102198 | 3000544 | SCOP2 (2022-06-29) |
B | SCOP2B Superfamily | Thymidylate synthase/dCMP hydroxymethylase | 8102198 | 3000544 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Thymidylat_synt | e7ccaA1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
B | Thymidylat_synt | e7ccaB1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00303 | Thymidylate synthase (Thymidylat_synt) | Thymidylate synthase | This is a family of proteins that are flavin-dependent thymidylate synthases. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR045097 | Thymidylate synthase/dCMP hydroxymethylase | Family | |
IPR020940 | Thymidylate synthase, active site | Active Site | |
IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily | Homologous Superfamily | |
IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain | Domain | |
IPR000398 | Thymidylate synthase | Family |