Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyLDH/MDH/AglA-like 8057308 3000039 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALdh_1_C_13e7dbkA1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
ALdh_1_Ne7dbkA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
BLdh_1_C_13e7dbkB1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
BLdh_1_Ne7dbkB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
CLdh_1_C_13e7dbkC1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
CLdh_1_Ne7dbkC2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
DLdh_1_C_13e7dbkD1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
DLdh_1_Ne7dbkD2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
ELdh_1_C_13e7dbkE1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
ELdh_1_Ne7dbkE2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
FLdh_1_C_13e7dbkF1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
FLdh_1_Ne7dbkF2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
GLdh_1_C_13e7dbkG1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
GLdh_1_Ne7dbkG2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
HLdh_1_C_13e7dbkH1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
HLdh_1_Ne7dbkH2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02866lactate/malate dehydrogenase, alpha/beta C-terminal domain (Ldh_1_C)lactate/malate dehydrogenase, alpha/beta C-terminal domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.
Domain
A, B, C, D, E
PF00056lactate/malate dehydrogenase, NAD binding domain (Ldh_1_N)lactate/malate dehydrogenase, NAD binding domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
L-lactate dehydrogenase B chain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR011304L-lactate dehydrogenaseFamily
A, B, C, D, E
IPR018177L-lactate dehydrogenase, active siteActive Site
A, B, C, D, E
IPR015955Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalHomologous Superfamily
A, B, C, D, E
IPR001557L-lactate/malate dehydrogenaseFamily
A, B, C, D, E
IPR001236Lactate/malate dehydrogenase, N-terminalDomain
A, B, C, D, E
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR022383Lactate/malate dehydrogenase, C-terminalDomain