Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
A [auth D]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
B [auth A]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
D [auth F]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
E [auth B]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
F [auth E]SCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyProtein kinase-like (PK-like) 8043964 3000066 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth D]Pkinase_Tyre7jxpD1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
B [auth A]Pkinase_Tyre7jxpA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
D [auth F]Pkinase_Tyre7jxpF1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
E [auth B]Pkinase_Tyre7jxpB1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
F [auth E]Pkinase_Tyre7jxpE1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)
CPkinase_Tyre7jxpC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Pkinase_TyrECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF07714Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)Protein tyrosine and serine/threonine kinaseProtein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Epidermal growth factor receptor

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR016245Tyrosine protein kinase, EGF/ERB/XmrK receptorFamily
IPR020635Tyrosine-protein kinase, catalytic domainDomain
IPR000719Protein kinase domainDomain
IPR032778Growth factor receptor domain 4Domain
IPR006212Furin-like repeatRepeat
IPR017441Protein kinase, ATP binding siteBinding Site
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
IPR009030Growth factor receptor cysteine-rich domain superfamilyHomologous Superfamily
IPR008266Tyrosine-protein kinase, active siteActive Site
IPR036941Receptor L-domain superfamilyHomologous Superfamily
IPR049328Epidermal growth factor receptor-like, transmembrane-juxtamembrane segmentDomain
IPR000494Receptor L-domainDomain
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
IPR006211Furin-like cysteine-rich domainDomain
IPR050122Receptor Tyrosine KinaseFamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP00533