Annotations: 7LVB

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth D]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
B [auth E]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
C [auth F]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
D [auth G]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
E [auth H]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
F [auth A]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
G [auth B]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
H [auth C]	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Bacterial enterotoxins	8080121	3000434	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	Enterotoxin_b	e7lvbD1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
B [auth E]	Enterotoxin_b	e7lvbE1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
C [auth F]	Enterotoxin_b	e7lvbF1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
D [auth G]	Enterotoxin_b	e7lvbG1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
E [auth H]	Enterotoxin_b	e7lvbH1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
F [auth A]	Enterotoxin_b	e7lvbA1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
G [auth B]	Enterotoxin_b	e7lvbB1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
H [auth C]	Enterotoxin_b	e7lvbC1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
I	Enterotoxin_b	e7lvbI1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)
J	Enterotoxin_b	e7lvbJ1	A: beta barrels	X: OB-fold	H: Bacterial enterotoxins (From Topology)	T: Bacterial enterotoxins	F: Enterotoxin_b	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], F [auth A], G [auth B], H [auth C], I, J	PF01376	Heat-labile enterotoxin beta chain (Enterotoxin_b)	Heat-labile enterotoxin beta chain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], F [auth A], G [auth B], H [auth C], I, J	Cholera enterotoxin B-subunit,Surface protein gp120	structural molecule activity binding galactose binding monosaccharide binding carbohydrate binding small molecule binding host cell surface binding toxin activity	viral process membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host cellular process apoptotic process cell death viral process membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host cellular process apoptotic process cell death programmed cell death cellular response to stimulus regulation of cellular process response to stimulus positive regulation of phosphorylation positive regulation of phosphate metabolic process cell communication regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process signal transduction protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein regulation of biological process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification metabolic process regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process signaling regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process positive regulation of cellular process cell surface receptor signaling pathway regulation of tyrosine phosphorylation of STAT protein biological regulation regulation of peptidyl-tyrosine phosphorylation regulation of macromolecule metabolic process positive regulation of tyrosine phosphorylation of STAT protein regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT	cellular anatomical structure membrane virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endosome membrane host cell cytoplasm host cell part host cell endosome cellular anatomical structure membrane virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endosome membrane host cell cytoplasm host cell part host cell endosome host intracellular region viral membrane viral envelope host cell plasma membrane periplasmic space protein-containing complex catalytic complex extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], F [auth A], G [auth B], H [auth C], I, J	IPR000777	Human immunodeficiency virus 1, envelope glycoprotein Gp120	Domain
A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], F [auth A], G [auth B], H [auth C], I, J	IPR036377	Gp120 core superfamily	Homologous Superfamily
A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], F [auth A], G [auth B], H [auth C], I, J	IPR000328	Retroviral envelope protein GP41-like	Domain
A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], F [auth A], G [auth B], H [auth C], I, J	IPR001835	Heat-labile enterotoxin, B chain	Family
A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], A [auth D], B [auth E], C [auth F], D [auth G], E [auth H], F [auth A], G [auth B], H [auth C], I, J	IPR008992	Enterotoxin	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.