Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8044103 3001442 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8044103 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recep_1e7nfbA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)
BHormone_recep_1e7nfbB1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Estrogen receptor
C, D
Nuclear receptor coactivator 2

InterPro: Protein Family Classification InterPro Database Homepage

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B
PharosP03372
C, D
PharosQ15596

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
C, D
ACE RESIDAA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354

PSI-MOD :  N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359