The influenza virus neuramidase is a concanovin A-like lectin/glucanase. This glycoside hydrolase is composed of a central, veta-propeller catalytic domain flanked by two lectin-like domains. NA is involved in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for the cholera toxin. The enzyme catalyses the hydrolysis of glycoside linkages between terminal sialic acids and adjacent sugar moieties. NA presents an excellent target for drug design against cholera.
Defined by 5 residues: ASP:A-70 [auth A-151]GLU:A-197 [auth A-277]ARG:A-212 [auth A-292]ARG:A-290 [auth A-371]TYR:A-324 [auth A-406]