7OWM

HsNMT1 in complex with both MyrCoA and HCPA substrate peptide GKQNSKLR

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032317	3000403	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032315	3000403	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032315	3000403	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8032317	3000403	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NMT	e7owmA2	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: NMT	ECOD (1.6)
A	NMT_C	e7owmA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: NMT_C	ECOD (1.6)
B	NMT	e7owmB2	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: NMT	ECOD (1.6)
B	NMT_C	e7owmB1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: NMT_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01233	Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain (NMT)	Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	Domain
A, B	PF02799	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (NMT_C)	Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain	The N and C-terminal domains of NMT are structurally similar, each adopting an acyl-CoA N-acyltransferase-like fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Glycylpeptide N-tetradecanoyltransferase 1	myristoyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity catalytic activity, acting on a protein peptidyl-lysine N6-myristoyltransferase activity glycylpeptide N-tetradecanoyltransferase activity N-acyltransferase activity	protein localization regulation of localization establishment of protein localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process positive regulation of establishment of protein localization localization cellular macromolecule localization positive regulation of cellular process regulation of biological process biological regulation regulation of establishment of protein localization protein localization regulation of localization establishment of protein localization cellular localization regulation of cellular process regulation of protein localization positive regulation of biological process positive regulation of establishment of protein localization localization cellular macromolecule localization positive regulation of cellular process regulation of biological process biological regulation regulation of establishment of protein localization establishment of localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of cellular localization macromolecule localization protein localization to organelle positive regulation of protein localization protein localization to mitochondrion cellular process establishment of protein localization to mitochondrion positive regulation of establishment of protein localization to mitochondrion lipoprotein biosynthetic process lipoprotein metabolic process primary metabolic process N-terminal protein lipidation macromolecule biosynthetic process N-terminal protein myristoylation protein acylation protein lipidation biosynthetic process protein myristoylation N-terminal protein amino acid modification peptidyl-glycine modification macromolecule modification peptidyl-amino acid modification metabolic process N-terminal peptidyl-glycine N-myristoylation protein metabolic process macromolecule metabolic process protein modification process ketone metabolic process localization within membrane protein localization to membrane cellular response to stimulus response to light stimulus response to stimulus regulation of response to external stimulus signaling regulation of opsin-mediated signaling pathway regulation of signal transduction detection of abiotic stimulus cellular response to environmental stimulus cell communication cellular response to light stimulus signal transduction regulation of G protein-coupled receptor signaling pathway detection of light stimulus phototransduction detection of external stimulus regulation of signaling detection of visible light response to external stimulus cellular response to radiation detection of stimulus regulation of response to stimulus regulation of cell communication response to radiation response to abiotic stimulus G protein-coupled receptor signaling pathway cellular response to abiotic stimulus G protein-coupled opsin signaling pathway phototransduction, visible light developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane
C	Neuron-specific calcium-binding protein hippocalcin	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding kinase binding enzyme binding cytoskeletal protein binding actin binding identical protein binding	regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization regulation of cellular process transport monoatomic ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of voltage-gated calcium channel activity calcium ion transport metal ion transport regulation of transporter activity regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport localization regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization regulation of cellular process transport monoatomic ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport regulation of voltage-gated calcium channel activity calcium ion transport metal ion transport regulation of transporter activity regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of monoatomic ion transmembrane transporter activity regulation of biological process regulation of transport regulation of monoatomic ion transport biological regulation inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport cellular process regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport developmental process multicellular organismal process sensory organ development eye development animal organ development retina development in camera-type eye visual system development multicellular organism development camera-type eye development anatomical structure development sensory system development system development ear development inner ear development cellular response to stimulus response to stimulus signaling intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction cellular response to metal ion cellular response to chemical stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion response to ketone response to oxygen-containing compound response to nitrogen compound response to organic cyclic compound response to ketamine cellular response to acid chemical cellular response to nitrogen compound cellular response to amino acid stimulus cellular response to L-glutamate response to amino acid cellular response to oxygen-containing compound response to acid chemical response to L-glutamate response to electrical stimulus cellular response to electrical stimulus response to abiotic stimulus cellular response to abiotic stimulus cellular response to environmental stimulus response to Aroclor 1254 protein localization cellular localization establishment of protein localization regulation of protein localization protein targeting positive regulation of biological process positive regulation of establishment of protein localization regulation of protein targeting to membrane cellular macromolecule localization regulation of protein localization to membrane positive regulation of cellular process establishment of protein localization to membrane regulation of establishment of protein localization positive regulation of protein localization to membrane localization within membrane protein localization to membrane protein targeting to membrane regulation of cellular localization regulation of protein targeting macromolecule localization positive regulation of protein localization positive regulation of protein targeting to membrane import into cell regulation of cellular component organization receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport vesicle-mediated transport in synapse cellular component organization establishment of localization in cell regulation of postsynaptic neurotransmitter receptor internalization regulation of biological quality cellular component organization or biogenesis regulation of endocytosis regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis endocytosis receptor-mediated endocytosis	somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body membrane intracellular anatomical structure cytoplasm cytosol neuron spine dendritic spine head synapse neuron projection dendritic spine somatodendritic compartment cell body cellular anatomical structure perikaryon neuronal cell body membrane intracellular anatomical structure cytoplasm cytosol neuron spine dendritic spine head synapse neuron projection dendritic spine plasma membrane bounded cell projection cell projection postsynapse cell junction dendrite dendritic tree glutamatergic synapse neuron projection cytoplasm cytoplasmic region plasma membrane bounded cell projection cytoplasm dendrite cytoplasm cell leading edge plasma membrane leading edge membrane neuron projection membrane cell periphery dendrite membrane plasma membrane region cell projection membrane neuronal cell body membrane cell body membrane axon

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR022676	Glycylpeptide N-tetradecanoyltransferase, N-terminal	Domain
A, B	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A, B	IPR022677	Glycylpeptide N-tetradecanoyltransferase, C-terminal	Domain
A, B	IPR000903	Glycylpeptide N-tetradecanoyltransferase	Family
A, B	IPR022678	Glycylpeptide N-tetradecanoyltransferase, conserved site	Conserved Site
C	IPR002048	EF-hand domain	Domain
C	IPR011992	EF-hand domain pair	Homologous Superfamily
C	IPR028846	Recoverin family	Family
C	IPR018247	EF-Hand 1, calcium-binding site	Binding Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P30419	astrocytic tumor glioblastoma malignant glioma ovarian cancer atypical teratoid rhabdoid tumor hypertensive disorder medulloblastoma primitive neuroectodermal tumor dermatomyositis lung cancer osteosarcoma psoriasis
C	Pharos: P84074	torsion dystonia 2 dystonic disorder astrocytic tumor glioblastoma malignant glioma Pick disease atypical teratoid rhabdoid tumor lung adenocarcinoma medulloblastoma pilocytic astrocytoma malignant ependymoma oligodendroglioma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.