7P46

Crystal Structure of Xanthomonas campestris Tryptophan 2,3-dioxygenase (TDO)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	indolic compounds 2, 3-dioxygenase-like	8043300	3001961	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Trp_dioxygenase	e7p46A1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
B	Trp_dioxygenase	e7p46B1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
C	Trp_dioxygenase	e7p46C1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
D	Trp_dioxygenase	e7p46D1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
E	Trp_dioxygenase	e7p46E1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
G	Trp_dioxygenase	e7p46G1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
H	Trp_dioxygenase	e7p46H1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)
F	Trp_dioxygenase	e7p46F1	A: alpha bundles	X: Indolic compounds 2,3-dioxygenase-like (From Topology)	H: Indolic compounds 2,3-dioxygenase-like (From Topology)	T: Indolic compounds 2,3-dioxygenase-like	F: Trp_dioxygenase	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF03301	Tryptophan 2,3-dioxygenase (Trp_dioxygenase)	Tryptophan 2,3-dioxygenase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	Tryptophan 2,3-dioxygenase	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen tryptophan 2,3-dioxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen catalytic activity dioxygenase activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	catabolic process oxoacid metabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process alpha-amino acid metabolic process cellular catabolic process non-proteinogenic amino acid metabolic process cellular ketone metabolic process carboxylic acid catabolic process indolalkylamine metabolic process small molecule metabolic process catabolic process oxoacid metabolic process aromatic amino acid family catabolic process indole-containing compound metabolic process amino acid metabolic process organic acid catabolic process organic acid metabolic process alpha-amino acid metabolic process cellular catabolic process non-proteinogenic amino acid metabolic process cellular ketone metabolic process carboxylic acid catabolic process indolalkylamine metabolic process small molecule metabolic process amino acid catabolic process aromatic amino acid metabolic process benzene-containing compound metabolic process cellular metabolic process carboxylic acid metabolic process primary metabolic process amine metabolic process kynurenine metabolic process tryptophan catabolic process to kynurenine alpha-amino acid catabolic process indole-containing compound catabolic process tryptophan catabolic process metabolic process cellular process small molecule catabolic process biogenic amine metabolic process acetyl-CoA metabolic process nucleobase-containing compound metabolic process acyl-CoA metabolic process nucleobase-containing small molecule metabolic process amide catabolic process phosphate-containing compound metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process purine-containing compound metabolic process organophosphate metabolic process tryptophan catabolic process to acetyl-CoA	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR004981	Tryptophan 2,3-dioxygenase	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR037217	Tryptophan/Indoleamine 2,3-dioxygenase-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.