7Q25

Crystal structure of Angiotensin-1 converting enzyme N-domain in complex with dual ACE/NEP inhibitor AD012

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Peptidase_M2	e7q25A1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M2	ECOD (1.6)
B	Peptidase_M2	e7q25B1	A: mixed a+b and a/b	X: Zincin-like	H: Metalloproteases (zincins) catalytic domain (From Topology)	T: Metalloproteases (zincins) catalytic domain	F: Peptidase_M2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01401	Angiotensin-converting enzyme (Peptidase_M2)	Angiotensin-converting enzyme	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Angiotensin-converting enzyme	peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding endopeptidase activity calmodulin binding mitogen-activated protein kinase binding peptidase activity catalytic activity, acting on a protein metallopeptidase activity hydrolase activity catalytic activity protein binding binding kinase binding enzyme binding protein kinase binding mitogen-activated protein kinase kinase binding endopeptidase activity calmodulin binding mitogen-activated protein kinase binding metallodipeptidase activity exopeptidase activity dipeptidase activity metalloexopeptidase activity metalloendopeptidase activity ion binding anion binding chloride ion binding small molecule binding heterocyclic compound binding peptidyl-dipeptidase activity cytoskeletal protein binding actin binding carboxypeptidase activity signaling receptor binding bradykinin receptor binding G protein-coupled receptor binding serine-type exopeptidase activity serine hydrolase activity serine-type peptidase activity tripeptidyl-peptidase activity cation binding transition metal ion binding zinc ion binding metal ion binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development response to stimulus response to chemical response to xenobiotic stimulus regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process regulation of primary metabolic process positive regulation of peptidyl-cysteine S-nitrosylation positive regulation of metabolic process positive regulation of protein modification process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process protein modification process regulation of biological process peptidyl-cysteine modification regulation of protein metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process peptidyl-cysteine S-nitrosylation regulation of peptidyl-cysteine S-nitrosylation macromolecule modification metabolic process macromolecule metabolic process protein nitrosylation regulation of metabolic process cellular catabolic process catabolic process cellular metabolic process cellular process peptide metabolic process peptide catabolic process system process circulatory system process regulation of blood pressure regulation of biological quality blood circulation spermatogenesis sexual reproduction multicellular organismal reproductive process male gamete generation gamete generation regulation of calcium ion import regulation of calcium ion transport regulation of localization transport regulation of transport regulation of monoatomic ion transport negative regulation of monoatomic ion transport negative regulation of biological process negative regulation of transport establishment of localization negative regulation of calcium ion import calcium ion transport metal ion transport negative regulation of calcium ion transport localization monoatomic ion transport calcium ion import monoatomic cation transport regulation of metal ion transport regulation of tube diameter regulation of tube size regulation of system process positive regulation of vasoconstriction regulation of blood circulation vascular process in circulatory system regulation of vasoconstriction positive regulation of multicellular organismal process regulation of multicellular organismal process blood vessel diameter maintenance vasoconstriction regulation of anatomical structure size regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone regulation of blood volume by renin-angiotensin regulation of systemic arterial blood pressure mediated by a chemical signal regulation of systemic arterial blood pressure endocrine process regulation of renal output by angiotensin positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process regulation of angiotensin metabolic process cellular response to nitrogen compound cellular response to stimulus response to angiotensin signaling response to peptide hormone angiotensin-activated signaling pathway cellular response to angiotensin cell communication cellular response to endogenous stimulus response to hormone signal transduction cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus G protein-coupled receptor signaling pathway neuropeptide catabolic process substance P catabolic process amide metabolic process regulation of biosynthetic process cellular biosynthetic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process post-transcriptional regulation of gene expression regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of cell motility regulation of smooth muscle cell migration smooth muscle cell migration muscle cell migration regulation of locomotion regulation of cell migration cell migration cell motility locomotion regulation of cellular component organization negative regulation of cellular component organization gap junction assembly regulation of gap junction assembly regulation of cellular component biogenesis cellular component organization cellular component biogenesis regulation of cell junction assembly negative regulation of gap junction assembly cell junction organization cellular component assembly negative regulation of cell junction assembly cell junction assembly negative regulation of cellular process cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization heart development angiogenesis involved in coronary vascular morphogenesis blood vessel morphogenesis tube development coronary vasculature development angiogenesis vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis coronary vasculature morphogenesis blood vessel development response to ketone response to lipid response to glucocorticoid response to corticosteroid response to steroid hormone response to dexamethasone response to organic cyclic compound response to laminar fluid shear stress response to stress response to fluid shear stress cell population proliferation mononuclear cell proliferation leukocyte proliferation response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus positive regulation of nervous system development regulation of developmental process cellular developmental process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process neurogenesis positive regulation of cell differentiation cell differentiation positive regulation of neurogenesis regulation of multicellular organismal development positive regulation of cell development nervous system development response to nutrient levels positive regulation of systemic arterial blood pressure positive regulation of blood pressure bradykinin catabolic process kidney development renal system development heart process regulation of heart contraction cardiac conduction regulation of heart rate by cardiac conduction heart contraction regulation of heart rate peptide hormone processing signaling receptor ligand precursor processing protein maturation proteolysis regulation of hormone levels regulation of systemic arterial blood pressure by circulatory renin-angiotensin hormone metabolic process regulation of angiotensin levels in blood protein processing angiotensin maturation amyloid-beta metabolic process regulation of stem cell proliferation hemopoiesis stem cell proliferation regulation of cell population proliferation hematopoietic stem cell proliferation regulation of hematopoietic stem cell proliferation multi-multicellular organism process female pregnancy multi-organism reproductive process neutrophil mediated immunity immune system process leukocyte mediated immunity myeloid leukocyte mediated immunity immune effector process homeostatic process cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus cellular response to mineralocorticoid stimulus response to mineralocorticoid cellular response to aldehyde cellular response to ketone cellular response to steroid hormone stimulus cellular response to aldosterone response to aldosterone response to alcohol cellular response to organic cyclic compound cellular response to corticosteroid stimulus cellular response to alcohol cellular response to lipid hexose transmembrane transport D-glucose import carbohydrate transport negative regulation of transmembrane transport negative regulation of D-glucose import regulation of D-glucose import negative regulation of D-glucose transmembrane transport transmembrane transport regulation of transmembrane transport D-glucose transmembrane transport regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport behavior eating behavior feeding behavior organic anion transport carboxylic acid transport secretion arachidonate transport lipid localization lipid transport organic acid transport arachidonate secretion monocarboxylic acid transport fatty acid transport icosanoid transport macromolecule localization icosanoid secretion long-chain fatty acid transport stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation blood vessel remodeling tissue remodeling response to thyroid hormone regulation of synaptic plasticity trans-synaptic signaling regulation of signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cell proliferation in bone marrow hormone catabolic process animal organ regeneration regeneration antigen processing and presentation antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of peptide antigen negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process embryo development ending in birth or egg hatching embryo development biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin respiratory tube development lung development respiratory system development lung alveolus development	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection basal part of cell basal plasma membrane plasma membrane region intracellular organelle intracellular anatomical structure lytic vacuole vacuole cytoplasm intracellular membrane-bounded organelle lysosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle brush border membrane cluster of actin-based cell projections brush border cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001548	Peptidase M2, peptidyl-dipeptidase A	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P12821	hypertensive disorder Alzheimer disease severe acute respiratory syndrome myocardial infarction atrial fibrillation kidney failure coronary artery disease IgA glomerulonephritis cerebrovascular disorder Gaucher disease congestive heart failure meningococcal infection kidney disease glycogen storage disease V Diabetes Mellitus, Experimental hypertensive disorder Alzheimer disease severe acute respiratory syndrome myocardial infarction atrial fibrillation kidney failure coronary artery disease IgA glomerulonephritis cerebrovascular disorder Gaucher disease congestive heart failure meningococcal infection kidney disease glycogen storage disease V Diabetes Mellitus, Experimental intracerebral hemorrhage cardiovascular disease granular cell carcinoma male infertility non-alcoholic fatty liver disease brain ischemia prostate cancer chronic kidney disease renal tubular dysgenesis of genetic origin tubular adenocarcinoma drug allergy viral pneumonia preeclampsia adenocarcinoma chronic beryllium disease pulmonary hypertension coronary restenosis microvascular complications of diabetes, susceptibility to, 3 depressive disorder hypotensive disorder autoimmune disease bipolar disorder peripheral arterial disease drug psychosis pneumonia gastric neoplasm lung benign neoplasm renal tubular dysgenesis respiratory system disease heart disease cribriform carcinoma schizophrenia hepatocellular carcinoma angioedema dementia autism diabetic kidney disease thrombotic disease obesity disorder inherited disease susceptibility peripheral vascular disease essential hypertension familial atrial fibrillation lung disease major affective disorder 2 heart failure cribriform carcinoma of breast hereditary diffuse gastric adenocarcinoma aortic disease staphylococcus aureus infection hyperglycemia atherosclerosis diabetes mellitus non-small cell lung carcinoma inborn carbohydrate metabolic disorder inherited lipid metabolism disorder facioscapulohumeral muscular dystrophy gastric cancer adult acute respiratory distress syndrome lung adenocarcinoma chronic obstructive pulmonary disease major depressive disorder COVID-19 sarcoidosis anemia staphylococcal infection Hodgkins lymphoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.