7RTB

Peptide-19 bound to the Glucagon-Like Peptide-1 Receptor (GLP-1R)

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
C [auth G]SCOP2B SuperfamilyTransducin (heterotrimeric G protein), gamma chain 8070798 3001771 SCOP2B (2022-06-29)
E [auth R]SCOP2B SuperfamilyG protein-coupled receptor-like 8091126 3000473 SCOP2B (2022-06-29)
E [auth R]SCOP2B SuperfamilyFnI-like domain 8086309 3000979 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARase7rtbA1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
C [auth G]G-gammae7rtbG1 A: extended segmentsX: Transducin (heterotrimeric G protein), gamma chain (From Topology)H: Transducin (heterotrimeric G protein), gamma chain (From Topology)T: Transducin (heterotrimeric G protein), gamma chainF: G-gammaECOD (1.6)
E [auth R]7tm_2e7rtbR1 A: alpha bundlesX: Family A G protein-coupled receptor-like (From Topology)H: Family A G protein-coupled receptor-like (From Topology)T: Family A G protein-coupled receptor-likeF: 7tm_2ECOD (1.6)
E [auth R]HRMe7rtbR2 A: few secondary structure elementsX: Hormone receptor domain (HRM, Pfam 02793) (From Topology)H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)T: Hormone receptor domain (HRM, Pfam 02793)F: HRMECOD (1.6)
BANAPC4_WD40_3e7rtbB1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: ANAPC4_WD40_3ECOD (1.6)
D [auth N]V-set_12e7rtbN1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
D [auth N]Heavy ChainIGHV3 -guanine nucleotide-binding protein g(s) subunit alphaisoforms short | guanine nucleotide-binding protein g(i)/g(s)/g(t) subunitbeta-1 SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00503G-protein alpha subunit (G-alpha)G-protein alpha subunitG proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like ...G proteins couple receptors of extracellular signals to intracellular signaling pathways. The G protein alpha subunit binds guanyl nucleotide and is a weak GTPase. A set of residues that are unique to G-alpha as compared to its ancestor the Arf-like family form a ring of residues centered on the nucleotide binding site [3]. A Ggamma is found fused to an inactive Galpha in the Dictyostelium protein gbqA [3].
Domain
E [auth R]PF02793Hormone receptor domain (HRM)Hormone receptor domain- Family
E [auth R]PF000027 transmembrane receptor (Secretin family) (7tm_2)7 transmembrane receptor (Secretin family)- Family
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
C [auth G]Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
E [auth R]Glucagon-like peptide 1 receptor
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
D [auth N]Nb35---
F [auth P]Peptide-19---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR001019Guanine nucleotide binding protein (G-protein), alpha subunitFamily
IPR011025G protein alpha subunit, helical insertionHomologous Superfamily
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
IPR000367G-protein alpha subunit, group SFamily
C [auth G]IPR015898G-protein gamma-like domainDomain
C [auth G]IPR001770G-protein, gamma subunitFamily
C [auth G]IPR036284G-protein gamma-like domain superfamilyHomologous Superfamily
E [auth R]IPR017983GPCR, family 2, secretin-like, conserved siteConserved Site
E [auth R]IPR050332G-protein coupled receptor 2Family
E [auth R]IPR003290GPCR, family 2, glucagon-like peptide-1/glucagon receptorFamily
E [auth R]IPR036445GPCR family 2, extracellular hormone receptor domain superfamilyHomologous Superfamily
E [auth R]IPR000832GPCR, family 2, secretin-likeFamily
E [auth R]IPR047033Glucagon-like peptide-1 receptor, 7TMDomain
E [auth R]IPR017981GPCR, family 2-like, 7TMDomain
E [auth R]IPR001879GPCR, family 2, extracellular hormone receptor domainDomain
E [auth R]IPR003292GPCR, family 2, glucagon-like peptide-1 receptorFamily
IPR019775WD40 repeat, conserved siteConserved Site
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
IPR016346Guanine nucleotide-binding protein, beta subunitFamily
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
IPR001632G-protein, beta subunitDomain
IPR001680WD40 repeatRepeat
IPR020472G-protein beta WD-40 repeatRepeat

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
Pharos:  P63092
C [auth G]Pharos:  P59768
E [auth R]Pharos:  P43220
Pharos:  P62873

Membrane Protein Annotation: OPM OPM Database Homepage

ChainsExternal LinkTypeClassSuperfamilyFamily
OPMTransmembraneAlpha-helical polytopicRhodopsin-like receptors and pumpsGPCR Secretin (B) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

ChainsResource LinkGroupSubgroupProtein
mpstrucTRANSMEMBRANE PROTEINS: ALPHA-HELICALG Protein-Coupled Receptors: Class B1GLP-1 receptor (GLP-1R) - Gs complex with bound Peptide-19