Annotations: 7RYL

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054547	3000071	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8107470	3000071	SCOP2B (2022-06-29)
A [auth C]	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054555	3000071	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth D]	DUF1968	e7rylD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF1968	ECOD (1.6)
B [auth D]	V-set_4	e7rylD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_4	ECOD (1.6)
A [auth C]	C1-set	e7rylC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
A [auth C]	V-set_3	e7rylC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth D]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
B [auth D]	PF09291	Domain of unknown function (DUF1968) (DUF1968)	Domain of unknown function (DUF1968)	Members of this family are found in mammalian T-cell antigen receptor, and adopt an immunoglobulin-like beta-sandwich fold, with seven strands in two beta-sheets in a Greek-key topology. Their exact function has not, as yet, been determined.	Domain
A [auth C]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain
A [auth C]	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth D]	T cell receptor delta variable 1,T cell receptor alpha chain constant	-	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus adaptive immune response biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus adaptive immune response cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway biological regulation T cell receptor signaling pathway regulation of response to stimulus regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response response to bacterium multicellular organismal process T cell activation cell activation alpha-beta T cell activation lymphocyte activation leukocyte activation	cell periphery protein-containing complex plasma membrane protein complex membrane plasma membrane plasma membrane signaling receptor complex membrane protein complex cellular anatomical entity T cell receptor complex receptor complex extracellular region extracellular space alpha-beta T cell receptor complex
A [auth C]	T cell receptor gamma variable 4,T cell receptor beta constant 1	-	biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus adaptive immune response biological process involved in interspecies interaction between organisms response to stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus immune system process defense response to other organism response to stress innate immune response response to external biotic stimulus adaptive immune response cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway biological regulation T cell receptor signaling pathway regulation of response to stimulus regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response multicellular organismal process T cell activation cell activation alpha-beta T cell activation lymphocyte activation leukocyte activation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex membrane protein complex T cell receptor complex receptor complex alpha-beta T cell receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth D]	IPR051006	T cell receptor variable domain	Family
B [auth D]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth D]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth D]	IPR013106	Immunoglobulin V-set domain	Domain
B [auth D]	IPR007110	Immunoglobulin-like domain	Domain
B [auth D]	IPR052051	T cell receptor complex component	Family
B [auth D]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth D]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth D]	IPR015370	T-cell receptor alpha chain, constant domain	Domain
A [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth C]	IPR013106	Immunoglobulin V-set domain	Domain
A [auth C]	IPR051117	T cell receptor gamma variable/constant region	Family
A [auth C]	IPR007110	Immunoglobulin-like domain	Domain
A [auth C]	IPR003597	Immunoglobulin C1-set	Domain
A [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth C]	IPR007110	Immunoglobulin-like domain	Domain
A [auth C]	IPR050380	Immune Recognition and Response Modulators	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth D]	Pharos: P01848	TCR-alpha-beta-positive T-cell deficiency B-cell chronic lymphocytic leukemia invasive ductal breast carcinoma malignant ependymoma Sjogren syndrome cutaneous lupus erythematosus large cell medulloblastoma medulloblastoma interstitial cystitis lung cancer osteosarcoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.