Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARIO1e7szcA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: RIO1ECOD (1.6)
CRIO1e7szcC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: RIO1ECOD (1.6)
DCGI-121e7szcD1 A: a+b two layersX: Alpha-beta plaitsH: PF0523-like (From Topology)T: PF0523-likeF: CGI-121ECOD (1.6)
BCGI-121e7szcB1 A: a+b two layersX: Alpha-beta plaitsH: PF0523-like (From Topology)T: PF0523-likeF: CGI-121ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF06293Lipopolysaccharide kinase (Kdo/WaaP) family (Kdo)Lipopolysaccharide kinase (Kdo/WaaP) family- Family
B, D
PF08617Kinase binding protein CGI-121 (CGI-121)Kinase binding protein CGI-121CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The K ...CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The KEOPS complex is involved in telomere uncapping and telomere elongation [2]. Interestingly this family also include archaeal homologues, formerly in the DUF509 family. A structure for these proteins has been solved by structural genomics.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
EKC/KEOPS complex subunit TP53RK
B, D
EKC/KEOPS complex subunit TPRKB