Annotations: 7V9B

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	14-3-3 protein	8082821	3001329	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	14-3-3	e7v9bA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: 14-3-3	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00244	14-3-3 protein (14-3-3)	14-3-3 protein	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	YWHAE/FAM22B fusion protein	histone deacetylase binding protein binding binding enzyme binding phosphoprotein binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity protein phosphatase binding histone deacetylase binding protein binding binding enzyme binding phosphoprotein binding protein-containing complex binding MHC protein complex binding MHC class II protein complex binding channel regulator activity ion channel regulator activity calcium channel regulator activity molecular function regulator activity transporter regulator activity protein phosphatase binding phosphatase binding cell adhesion molecule binding cadherin binding molecular function inhibitor activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity channel inhibitor activity potassium channel regulator activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding protein domain specific binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity phosphoserine residue binding protein phosphorylated amino acid binding protein heterodimerization activity protein dimerization activity scaffold protein binding molecular sequestering activity protein sequestering activity RNA binding organic cyclic compound binding nucleic acid binding transmembrane transporter binding	cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus intracellular signal transduction cellular response to stimulus cytoplasmic pattern recognition receptor signaling pathway regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus intracellular signal transduction cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response protein localization localization cellular localization cellular macromolecule localization macromolecule localization heart process multicellular organismal process regulation of heart rate by chemical signal system process regulation of heart contraction regulation of system process circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction regulation of heart rate by hormone blood circulation regulation of heart rate cellular response to heat cellular response to stress response to heat response to abiotic stimulus response to temperature stimulus inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis regulation of cytosolic calcium ion concentration cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis intracellular signaling cassette MAPK cascade developmental process head development forebrain development animal organ development brain development nervous system development pallium development cerebral cortex development multicellular organism development central nervous system development anatomical structure development telencephalon development system development establishment of protein localization protein targeting establishment of localization cardiac conduction regulation of heart rate by cardiac conduction toll-like receptor signaling pathway negative regulation of biological process regulation of signal transduction regulation of pattern recognition receptor signaling pathway regulation of toll-like receptor signaling pathway negative regulation of signaling negative regulation of cell communication negative regulation of cellular process regulation of signaling negative regulation of response to stimulus negative regulation of signal transduction negative regulation of toll-like receptor signaling pathway negative regulation of immune system process regulation of cell communication hippocampus development limbic system development regulation of mitotic cell cycle cell cycle regulation of cell cycle mitotic cell cycle membrane repolarization regulation of membrane repolarization regulation of membrane potential maintenance of protein location cytoplasmic sequestering of protein maintenance of location regulation of localization regulation of potassium ion transport transport monoatomic ion transmembrane transport potassium ion transmembrane transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport metal ion transport regulation of transporter activity monoatomic cation transmembrane transport monoatomic ion transport monoatomic cation transport regulation of metal ion transport regulation of potassium ion transmembrane transporter activity regulation of monoatomic ion transmembrane transporter activity regulation of transport regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of potassium ion transmembrane transport inorganic cation transmembrane transport transmembrane transport regulation of molecular function regulation of transmembrane transport potassium ion transport regulation of monoatomic cation transmembrane transport hippo signaling positive regulation of cell communication positive regulation of signal transduction regulation of intracellular signal transduction positive regulation of cellular process positive regulation of intracellular signal transduction positive regulation of hippo signaling regulation of hippo signaling positive regulation of signaling regulation of calcium ion transport negative regulation of monoatomic ion transport negative regulation of transport export across plasma membrane negative regulation of calcium ion export across plasma membrane calcium ion transport negative regulation of transmembrane transport regulation of calcium ion transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cation transmembrane transport regulation of calcium ion export across plasma membrane calcium ion export across plasma membrane export from cell negative regulation of calcium ion transport negative regulation of calcium ion transmembrane transport calcium ion transmembrane transport nitrogen compound transport regulation of protein localization nucleocytoplasmic transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization positive regulation of protein transport establishment of localization in cell positive regulation of intracellular transport nuclear export regulation of protein export from nucleus regulation of intracellular transport regulation of establishment of protein localization intracellular transport regulation of nucleocytoplasmic transport regulation of protein transport protein export from nucleus positive regulation of protein export from nucleus positive regulation of transport protein transport regulation of cellular localization positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport substantia nigra development midbrain development neural nucleus development protein localization to organelle protein localization to endoplasmic reticulum cardiac muscle cell membrane repolarization membrane repolarization during cardiac muscle cell action potential action potential cardiac muscle cell action potential membrane repolarization during action potential neuron migration cellular developmental process generation of neurons neurogenesis cell differentiation cell migration cell motility protein localization to nucleus	cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope cytoplasm organelle membrane cytosol anchoring junction cell junction focal adhesion cell-substrate junction pigment granule intracellular vesicle melanosome cytoplasmic vesicle nucleus endoplasmic reticulum endomembrane system
B	ARG-ARG-ARG-ALA-VAL-SEP-MET-ASP-ASN-SER-ASN	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding mitochondrial transcription factor activity kinase binding enzyme binding protein kinase binding chromatin binding chromatin DNA binding beta-catenin binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation response to stimulus response to chemical response to xenobiotic stimulus cellular response to stimulus cell surface receptor signaling pathway signaling canonical Wnt signaling pathway cell communication signal transduction Wnt signaling pathway cellular response to nutrient levels response to nutrient levels cellular response to stress response to stress response to starvation cellular response to glucose starvation cellular response to starvation response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus cell population proliferation regulation of cell population proliferation neural precursor cell proliferation regulation of neural precursor cell proliferation negative regulation of signaling regulation of canonical Wnt signaling pathway regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of programmed cell death regulation of apoptotic process positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process neuron apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of biosynthetic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process protein metabolic process regulation of metabolic process cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process positive regulation of metabolic process regulation of RNA metabolic process miRNA transcription positive regulation of biosynthetic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription response to oxidative stress cellular response to oxidative stress cellular response to chemical stress sexual reproduction reproductive process multicellular organismal reproductive process oogenesis cell development cellular process involved in reproduction in multicellular organism developmental maturation developmental process involved in reproduction female gamete generation gamete generation oocyte development anatomical structure maturation germ cell development oocyte maturation oocyte differentiation cell maturation signal transduction in absence of ligand extrinsic apoptotic signaling pathway apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand response to ketone response to lipid response to glucocorticoid response to oxygen-containing compound response to corticosteroid response to hormone response to steroid hormone response to dexamethasone response to organic cyclic compound regulation of hydrogen peroxide-mediated programmed cell death positive regulation of hydrogen peroxide-mediated programmed cell death programmed cell death in response to reactive oxygen species cellular response to reactive oxygen species hydrogen peroxide-mediated programmed cell death cellular response to oxygen-containing compound response to reactive oxygen species ovulation cycle process ovulation sex differentiation development of primary female sexual characteristics ovulation from ovarian follicle ovulation cycle development of primary sexual characteristics reproductive structure development rhythmic process gonad development reproductive system development female gonad development animal organ development female sex differentiation homeostatic process regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process regulation of multicellular organismal process myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion regulation of muscle adaptation muscle atrophy system process regulation of system process regulation of muscle atrophy muscle system process regulation of muscle system process positive regulation of response to stimulus muscle adaptation positive regulation of muscle atrophy positive regulation of muscle adaptation positive regulation of multicellular organismal process response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor response to immobilization stress response to water-immersion restraint stress negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process developmental growth ovarian follicle development growth antral ovarian follicle growth positive regulation of transcription by RNA polymerase II positive regulation of autophagy catabolic process autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process process utilizing autophagic mechanism neuronal stem cell population maintenance maintenance of cell number stem cell population maintenance initiation of primordial ovarian follicle growth head development brain morphogenesis brain development anatomical structure morphogenesis central nervous system development animal organ morphogenesis cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation positive regulation of cell activation T cell activation positive regulation of leukocyte activation T cell differentiation positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development positive regulation of regulatory T cell differentiation regulation of leukocyte cell-cell adhesion leukocyte differentiation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis regulation of cell-cell adhesion regulation of lymphocyte differentiation positive regulation of cell adhesion regulation of cell adhesion regulation of regulatory T cell differentiation cell activation regulation of T cell activation regulatory T cell differentiation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation positive regulation of endothelial cell apoptotic process endothelial cell apoptotic process regulation of endothelial cell apoptotic process reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process signal transduction by p53 class mediator DNA damage response, signal transduction by p53 class mediator intracellular signal transduction DNA damage response signal transduction in response to DNA damage response to fatty acid mitochondrial gene expression mitochondrial transcription mitochondrial RNA metabolic process cellular response to mineralocorticoid stimulus response to corticosterone response to mineralocorticoid cellular response to ketone cellular response to steroid hormone stimulus cellular response to hormone stimulus response to alcohol cellular response to organic cyclic compound cellular response to glucocorticoid stimulus cellular response to corticosterone stimulus cellular response to corticosteroid stimulus cellular response to alcohol cellular response to lipid cellular response to nitrogen compound response to nitrogen compound cellular response to amyloid-beta response to amyloid-beta	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle RNA polymerase II transcription repressor complex protein-containing complex nucleus cellular anatomical structure intracellular anatomical structure cytoplasm cytosol intracellular organelle organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle RNA polymerase II transcription repressor complex protein-containing complex nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle transcription repressor complex mitochondrial membrane mitochondrion membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen mitochondrial matrix

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR023409	14-3-3 protein, conserved site	Conserved Site
A	IPR023410	14-3-3 domain	Domain
A	IPR036815	14-3-3 domain superfamily	Homologous Superfamily
A	IPR000308	14-3-3 protein	Family
B	IPR001766	Fork head domain	Domain
B	IPR032068	FOXO protein, KIX-binding domain	Domain
B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR030456	Fork head domain conserved site 2	Conserved Site
B	IPR032067	FOXO protein, transactivation domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P62258	Miller-Dieker lissencephaly syndrome endometrioid stromal sarcoma chromosome 17p13.3 duplication syndrome Neoplasm Metastasis schizophrenia Parkinson disease psoriasis atrial fibrillation Down syndrome Gerstmann-Straussler-Scheinker syndrome large cell medulloblastoma osteosarcoma Pick disease rheumatoid arthritis atypical teratoid rhabdoid tumor Miller-Dieker lissencephaly syndrome endometrioid stromal sarcoma chromosome 17p13.3 duplication syndrome Neoplasm Metastasis schizophrenia Parkinson disease psoriasis atrial fibrillation Down syndrome Gerstmann-Straussler-Scheinker syndrome large cell medulloblastoma osteosarcoma Pick disease rheumatoid arthritis atypical teratoid rhabdoid tumor clear cell sarcoma of kidney hereditary spastic paraplegia malignant ependymoma ovarian cancer plasma cell myeloma bipolar disorder dermatomyositis interstitial cystitis medulloblastoma oligodendroglioma
B	Pharos: O43524	salivary gland adenoid cystic carcinoma cancer Diabetes Mellitus, Experimental obesity disorder adenoid cystic carcinoma experimental autoimmune encephalomyelitis non-small cell lung carcinoma ovarian cancer astrocytic tumor chronic obstructive pulmonary disease lung adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm sinusitis attention deficit hyperactivity disorder, inattentive type cystic fibrosis salivary gland adenoid cystic carcinoma cancer Diabetes Mellitus, Experimental obesity disorder adenoid cystic carcinoma experimental autoimmune encephalomyelitis non-small cell lung carcinoma ovarian cancer astrocytic tumor chronic obstructive pulmonary disease lung adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm sinusitis attention deficit hyperactivity disorder, inattentive type cystic fibrosis myopathy osteosarcoma psoriasis spina bifida bipolar disorder dermatomyositis

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.