7X8P

Frizzled 2 CRD in complex with pF7_A5 Fab

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Frizzled domain-like	8083834	3001950	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Frizzled domain-like	8083834	3001950	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fz	e7x8pA1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Fz	ECOD (1.6)
D	Fz	e7x8pD1	A: few secondary structure elements	X: Frizzled cysteine-rich domain-related (From Topology)	H: Frizzled cysteine-rich domain-related (From Topology)	T: Frizzled cysteine-rich domain-related	F: Fz	ECOD (1.6)
B	C1-set	e7x8pB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
B	V-set_3	e7x8pB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
E	C1-set	e7x8pE2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set	ECOD (1.6)
E	V-set_3	e7x8pE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_3	ECOD (1.6)
C	C1-set_1	e7x8pC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
C	V-set_12	e7x8pC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
F	C1-set_1	e7x8pF2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)
F	V-set_12	e7x8pF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B, E	Light Chain	IGLV3	Lambda	frizzled-2	SAbDab (2024-11-08)
C, F	Heavy Chain	IGHV3	-	frizzled-2	SAbDab (2024-11-08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D	PF01392	Fz domain (Fz)	Fz domain	Also known as the CRD (cysteine rich domain), the C6 box in MuSK receptor. This domain of unknown function has been independently identified by several groups [1,2,3,4]. The domain contains 10 conserved cysteines.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D	Frizzled-2	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity Wnt receptor activity G protein-coupled receptor activity protein binding binding PDZ domain binding protein domain specific binding Wnt-protein binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway multicellular organismal process system process cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway multicellular organismal process system process sensory perception of chemical stimulus sensory perception nervous system process sensory perception of smell non-canonical Wnt signaling pathway positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process developmental process heart development cardiac chamber morphogenesis animal organ development heart morphogenesis ventricular septum development circulatory system development anatomical structure morphogenesis multicellular organism development cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis anatomical structure development cardiac chamber development membranous septum morphogenesis animal organ morphogenesis cardiac ventricle development system development cell-cell signaling hard palate development secondary palate development roof of mouth development mechanoreceptor differentiation inner ear receptor cell development cellular developmental process ear development sensory organ development cell development nervous system development inner ear receptor cell differentiation generation of neurons neurogenesis neuron differentiation inner ear development cell differentiation neuron development muscle structure development muscle organ development tissue development muscle tissue morphogenesis tissue morphogenesis muscular septum morphogenesis muscle organ morphogenesis epithelium development endothelial cell differentiation endothelium development epithelial cell differentiation Wnt signaling pathway, planar cell polarity pathway ear morphogenesis embryonic organ morphogenesis embryonic morphogenesis embryo development sensory organ morphogenesis cochlea development inner ear morphogenesis cochlea morphogenesis embryonic organ development positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process outflow tract morphogenesis	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure intracellular vesicle intracellular organelle bounding membrane of organelle cytoplasmic vesicle vesicle membrane clathrin-coated vesicle endocytic vesicle membrane coated vesicle vesicle endocytic vesicle clathrin-coated vesicle membrane clathrin-coated endocytic vesicle membrane membrane intracellular membrane-bounded organelle clathrin-coated endocytic vesicle cytoplasmic vesicle membrane coated vesicle membrane organelle cytoplasm organelle membrane cell periphery plasma membrane
B, E	Antibody pF7_A5 Fab, Light chain	-	-	-
C, F	Antibody pF7_A5 Fab, Heavy chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D	IPR036790	Frizzled cysteine-rich domain superfamily	Homologous Superfamily
A, D	IPR041778	Frizzled 2, cysteine-rich domain	Domain
A, D	IPR017981	GPCR, family 2-like, 7TM	Domain
A, D	IPR015526	Frizzled/secreted frizzled-related protein	Family
A, D	IPR000539	Frizzled/Smoothened, 7TM	Domain
A, D	IPR020067	Frizzled domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D	Pharos: Q14332	malignant colon neoplasm Robinow syndrome atypical teratoid rhabdoid tumor breast cancer glioblastoma malignant glioma Omodysplasia 2 primitive neuroectodermal tumor tuberculosis autosomal dominant omodysplasia colonic neoplasm malignant mesothelioma ovarian cancer psoriasis benign colon neoplasm malignant colon neoplasm Robinow syndrome atypical teratoid rhabdoid tumor breast cancer glioblastoma malignant glioma Omodysplasia 2 primitive neuroectodermal tumor tuberculosis autosomal dominant omodysplasia colonic neoplasm malignant mesothelioma ovarian cancer psoriasis benign colon neoplasm gastric carcinoma malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.