Annotations: 7Y7S

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055682	3001330	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055683	3001330	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055682	3001330	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Two-barrel nucleic acid polymerases	8055683	3001330	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RdRP_3rd	e7y7sA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_3rd	ECOD (1.6)
A	RdRP_2nd	e7y7sA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_2nd	ECOD (1.6)
A	RdRP_4th	e7y7sA2	A: alpha complex topology	X: RNAi polymerase helical domain (From Topology)	H: RNAi polymerase helical domain (From Topology)	T: RNAi polymerase helical domain	F: RdRP_4th	ECOD (1.6)
A	RdRP_1st	e7y7sA4	A: a+b complex topology	X: RNAi polymerase N-terminal domain (From Topology)	H: RNAi polymerase N-terminal domain (From Topology)	T: RNAi polymerase N-terminal domain	F: RdRP_1st	ECOD (1.6)
B	RdRP_3rd	e7y7sB1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_3rd	ECOD (1.6)
B	RdRP_2nd	e7y7sB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RdRP_2nd	ECOD (1.6)
B	RdRP_4th	e7y7sB3	A: alpha complex topology	X: RNAi polymerase helical domain (From Topology)	H: RNAi polymerase helical domain (From Topology)	T: RNAi polymerase helical domain	F: RdRP_4th	ECOD (1.6)
B	RdRP_1st	e7y7sB4	A: a+b complex topology	X: RNAi polymerase N-terminal domain (From Topology)	H: RNAi polymerase N-terminal domain (From Topology)	T: RNAi polymerase N-terminal domain	F: RdRP_1st	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05183	RNA dependent RNA polymerase (RdRP)	RNA dependent RNA polymerase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	RNA-dependent RNA polymerase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups RNA binding nucleic acid binding guanyl nucleotide binding GTP binding guanyl ribonucleotide binding cation binding metal ion binding identical protein binding protein binding	regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	-
C, D [auth I]	DNA (5'-D(GPAPAPCPTPAPTPGPGPTPCPGPGPA)-3')	-	-	-
E [auth D], F [auth J]	RNA (5'-R(UPCPCPGPAPCP*C)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007855	RNA-dependent RNA polymerase, eukaryotic-type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.