7YIS

Crystal structure of N-terminal PH domain of ARAP3 protein in complex with inositol 1,3,4,5-tetrakisphosphate

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e7yisA1	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3	ion binding binding anion binding phosphatidylinositol-3,4-bisphosphate binding small molecule binding phosphatidylinositol-3,4,5-trisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding cation binding metal ion binding	cellular component organization organelle organization cellular process cellular component organization or biogenesis cytoskeleton organization localization transport establishment of localization vesicle-mediated transport cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling cellular component organization organelle organization cellular process cellular component organization or biogenesis cytoskeleton organization localization transport establishment of localization vesicle-mediated transport cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation signal transduction cell communication	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle ruffle cell periphery plasma membrane cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle ruffle cell periphery plasma membrane membrane cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR052227	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein	Family
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR000159	Ras-associating domain	Domain
A	IPR037858	ARAP, RhoGAP domain	Domain
A	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A	IPR001164	Arf GTPase activating protein	Domain
A	IPR001660	Sterile alpha motif domain	Domain
A	IPR038508	ArfGAP domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8WWN8	HIV infectious disease colorectal cancer HIV Coinfection lung cancer medulloblastoma ovarian cancer diffuse large B-cell lymphoma malignant glioma non-small cell lung carcinoma primitive neuroectodermal tumor glioblastoma lung adenocarcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.