Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth B]Nsp1e8aysB1 A: beta complex topologyX: Coronavirus nsp1 (From Topology)H: Coronavirus nsp1 (From Topology)T: Coronavirus nsp1F: Nsp1ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B]PF11501Betacoronavirus replicase NSP1 (bCoV_NSP1)Betacoronavirus replicase NSP1- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B]Host translation inhibitor nsp1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B]IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
A [auth B]IPR042515Non-structural protein NSP15, N-terminal domain superfamily, coronavirusHomologous Superfamily
A [auth B]IPR043174Non-structural protein NSP15, middle domain superfamilyHomologous Superfamily
A [auth B]IPR044315Nonstructural protein 14, betacoronavirusDomain
A [auth B]IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
A [auth B]IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
A [auth B]IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
A [auth B]IPR046441RNA-dependent RNA polymerase, coronavirusDomain
A [auth B]IPR044863Nidovirus RdRp-associated nucleotidyl transferase (NiRAN) domainDomain
A [auth B]IPR044343Nonstructural protein 13, 1B domain, coronavirusDomain
A [auth B]IPR038166Polyprotein cleavage domain PL2pro superfamily, betacoronavirusHomologous Superfamily
A [auth B]IPR037227Endoribonuclease EndoU-likeHomologous Superfamily
A [auth B]IPR027352Nonstructural protein 13, zinc-binding domain, coronavirus-likeDomain
A [auth B]IPR009003Peptidase S1, PA clanHomologous Superfamily
A [auth B]IPR013016Peptidase C16, coronavirusDomain
A [auth B]IPR009466Non-structural protein 14, coronavirusDomain
A [auth B]IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
A [auth B]IPR046436Nidovirus 3'-5' exoribonuclease domainDomain
A [auth B]IPR047570NSP12, interface domain, coronavirusDomain
A [auth B]IPR018995RNA synthesis protein NSP10, coronavirusDomain
A [auth B]IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
A [auth B]IPR050534Coronaviruses polyprotein 1abFamily
A [auth B]IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
A [auth B]IPR043606Coronavirus replicase NSP15, N-terminal oligomerizationDomain
A [auth B]IPR044330Nonstructural protein 15, N-terminal domain, alpha/beta-coronavirusDomain
A [auth B]IPR041679DNA2/NAM7 helicase-like, C-terminalDomain
A [auth B]IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
A [auth B]IPR014828Non-structural protein NSP7, coronavirusDomain
A [auth B]IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
A [auth B]IPR014829Non-structural protein NSP8, coronavirusDomain
A [auth B]IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
A [auth B]IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A [auth B]IPR044389Non-structural protein 2, SARS-CoV-likeDomain
A [auth B]IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A [auth B]IPR008740Peptidase C30, coronavirusDomain
A [auth B]IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
A [auth B]IPR047573Non-structural protein 2, middle domain, coronavirusDomain
A [auth B]IPR049894Coronavirus NSP3, 3Ecto domainDomain
A [auth B]IPR043472Macro domain-likeHomologous Superfamily
A [auth B]IPR043609NendoU domain, nidovirusDomain
A [auth B]IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
A [auth B]IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
A [auth B]IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
A [auth B]IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
A [auth B]IPR044351RNA-dependent RNA polymerase, SARS-CoV-likeDomain
A [auth B]IPR024358Non-structural protein NSP3, N-terminal, betacoronavirusDomain
A [auth B]IPR048673Nonstructural protein 13, stalk domain, coronavirusDomain
A [auth B]IPR046435NSP14, guanine-N7-methyltransferase domain, coronavirusDomain
A [auth B]IPR009469RNA-dependent RNA polymerase, N-terminal, coronavirusDomain
A [auth B]IPR043611Coronavirus replicase NSP3, C-terminalDomain
A [auth B]IPR044864Non-structural protein NSP3, SUD-N (Mac2) domain, betacoronavirusDomain
A [auth B]IPR047566Coronavirus replicase NSP3, Y domainDomain
A [auth B]IPR048672Nonstructural protein 13, zinc-binding domain, coronavirusDomain
A [auth B]IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
A [auth B]IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A [auth B]IPR043608Nonstructural protein 15, middle domain, coronavirusDomain
A [auth B]IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
A [auth B]IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
A [auth B]IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
A [auth B]IPR043610Non-structural protein 6, coronavirusDomain
A [auth B]IPR027351(+) RNA virus helicase core domainDomain
A [auth B]IPR044322Nonstructural protein 15, middle domain, alpha/betacoronavirusDomain
A [auth B]IPR009461Non-structural protein NSP16, coronavirus-likeDomain
A [auth B]IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
A [auth B]IPR043478Non-structural protein NSP3, SUD-N (Mac2) domain superfamily, betacoronavirusHomologous Superfamily
A [auth B]IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
A [auth B]IPR046442NSP1, C-terminal domain, betacoronavirusDomain
A [auth B]IPR001205RNA-directed RNA polymerase, C-terminal domainDomain
A [auth B]IPR044401NSP15, NendoU domain, coronavirusDomain
A [auth B]IPR014822Non-structural protein NSP9, coronavirusDomain
A [auth B]IPR038030NSP1 globular domain superfamily, betacoronavirusHomologous Superfamily
A [auth B]IPR021590NSP1, globular domain, betacoronavirusDomain
A [auth B]IPR044367Non-structural protein 6, betacoronavirusDomain
A [auth B]IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
A [auth B]IPR046440Arterivirus Nsp11 N-terminal/Coronavirus NSP15 middle domainDomain
A [auth B]IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
A [auth B]IPR046438Nidovirus 2-O-methyltransferaseDomain
A [auth B]IPR002589Macro domainDomain
A [auth B]IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
A [auth B]IPR044371Non-structural protein 3, X-domain-likeDomain
A [auth B]IPR007094RNA-directed RNA polymerase, catalytic domainDomain