Annotations: 8BEH

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth T]	SCOP2B Superfamily	ACP-like	8101545	3001805	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth L]	Proton_antipo_M	e8behL1	A: alpha complex topology	X: Sodium/proton antiporter subunits-like (From Homology)	H: Sodium/proton antiporter subunits-like	T: NADH-quinone oxidoreductase subunit L (NuoL)-related	F: Proton_antipo_M	ECOD (1.6)
C [auth T]	PP-binding	e8behT1	A: alpha bundles	X: ACP-like	H: Acyl-carrier protein (ACP) (From Topology)	T: Acyl-carrier protein (ACP)	F: PP-binding	ECOD (1.6)
G [auth j]	NADH_B2	e8behj1	A: extended segments	X: Mitochondrial complex I, AGGG subunit (From Topology)	H: Mitochondrial complex I, AGGG subunit (From Topology)	T: Mitochondrial complex I, AGGG subunit	F: NADH_B2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth L]	PF00361	Proton-conducting membrane transporter (Proton_antipo_M)	Proton-conducting membrane transporter	-	Family
A [auth L]	PF06455	NADH dehydrogenase subunit 5 C-terminus (NADH5_C)	NADH dehydrogenase subunit 5 C-terminus	-	Family
A [auth L]	PF00662	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus (Proton_antipo_N)	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	Family
C [auth T]	PF00550	Phosphopantetheine attachment site (PP-binding)	Phosphopantetheine attachment site	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ...	A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth L]	NADH-ubiquinone oxidoreductase chain 5	oxidoreductase activity oxidoreductase activity, acting on NAD(P)H catalytic activity NADH dehydrogenase activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity oxidoreductase activity, acting on NAD(P)H catalytic activity NADH dehydrogenase activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor electron transfer activity active monoatomic ion transmembrane transporter activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport monoatomic cation transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure plastid organelle cytoplasm intracellular membrane-bounded organelle
B [auth M]	NADH-ubiquinone oxidoreductase chain 4	binding quinone binding ubiquinone binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity binding quinone binding ubiquinone binding small molecule binding monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds respiratory electron transport chain ATP synthesis coupled electron transport electron transport chain metabolic process cellular process generation of precursor metabolites and energy electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport monoatomic cation transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure plastid organelle cytoplasm intracellular membrane-bounded organelle
C [auth T]	Acyl carrier protein 1, mitochondrial	phosphopantetheine-dependent carrier activity prosthetic group binding binding acyl carrier activity molecular carrier activity ACP phosphopantetheine attachment site binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport fatty acid metabolic process monocarboxylic acid biosynthetic process transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process biosynthetic process small molecule metabolic process metabolic process monocarboxylic acid metabolic process lipid metabolic process aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, NADH to ubiquinone respiratory electron transport chain mitochondrial ATP synthesis coupled electron transport	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen
D [auth c]	Transmembrane protein	-	metabolic process cellular process cellular metabolic compound salvage photorespiration	respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex cellular anatomical structure transmembrane transporter complex respiratory chain complex I oxidoreductase complex membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane
E [auth g]	ESSS subunit of NADH:ubiquinone oxidoreductase (Complex I) protein	-	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle
F [auth i]	At1g67350	-	metabolic process cellular process cellular metabolic compound salvage photorespiration	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex mitochondrial membrane organelle envelope mitochondrial envelope organelle membrane
G [auth j]	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2	-	-	-
H [auth k]	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-A	-	electron transport chain metabolic process cellular process generation of precursor metabolites and energy	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle
I [auth l]	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	-	-	-
J [auth m]	AT2G31490 protein	-	metabolic process cellular process cellular metabolic compound salvage photorespiration	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex mitochondrial membrane organelle envelope mitochondrial envelope organelle membrane
L [auth o]	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	-	metabolic process cellular process cellular metabolic compound salvage photorespiration	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex mitochondrial intermembrane space membrane-enclosed lumen intracellular organelle lumen organelle envelope lumen organelle envelope organelle lumen mitochondrial envelope mitochondrial membrane organelle membrane
M [auth p]	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10-B	-	metabolic process cellular process cellular metabolic compound salvage photorespiration	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle mitochondrion organelle intracellular membrane-bounded organelle respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex mitochondrial membrane organelle envelope mitochondrial envelope organelle membrane
K [auth n]	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	-	metabolic process cellular process cellular metabolic compound salvage photorespiration carbohydrate metabolic process primary metabolic process aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy metabolic process cellular process cellular metabolic compound salvage photorespiration carbohydrate metabolic process primary metabolic process aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, NADH to ubiquinone respiratory electron transport chain mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle mitochondrial membrane organelle inner membrane membrane mitochondrial inner membrane organelle envelope mitochondrial envelope organelle membrane respiratory chain complex protein-containing complex catalytic complex membrane protein complex transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I oxidoreductase complex cell periphery plasma membrane plant-type vacuole vacuole

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth L]	IPR003945	NADH-quinone oxidoreductase, chain 5-like	Family
A [auth L]	IPR010934	NADH dehydrogenase subunit 5, C-terminal	Domain
A [auth L]	IPR001516	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminal	Domain
A [auth L]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit	Domain
A [auth L]	IPR018393	NADH-plastoquinone oxidoreductase, chain 5 subgroup	Family
B [auth M]	IPR003918	NADH:ubiquinone oxidoreductase	Family
B [auth M]	IPR010227	NADH-quinone oxidoreductase, chain M/4	Family
B [auth M]	IPR001750	NADH:quinone oxidoreductase/Mrp antiporter, membrane subunit	Domain
C [auth T]	IPR006162	Phosphopantetheine attachment site	PTM
C [auth T]	IPR009081	Phosphopantetheine binding ACP domain	Domain
C [auth T]	IPR036736	ACP-like superfamily	Homologous Superfamily
C [auth T]	IPR003231	Acyl carrier protein	Family
F [auth i]	IPR035204	NADH-ubiquinone oxidoreductase 11kDa subunit	Family
G [auth j]	IPR044980	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, plant/fungi	Family
H [auth k]	IPR012576	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	Family
I [auth l]	IPR038863	Putative NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	Family
L [auth o]	IPR008698	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7, NDUB7	Family
M [auth p]	IPR019377	NADH-ubiquinone oxidoreductase, subunit 10	Family
M [auth p]	IPR039993	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	Family
K [auth n]	IPR033034	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	Family
K [auth n]	IPR045292	NDUFB9, LYR domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth L], B [auth M], C [auth T], D [auth c], G [auth j] A [auth L], B [auth M], C [auth T], D [auth c], G [auth j], H [auth k], I [auth l], J [auth m], K [auth n], L [auth o], M [auth p]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex I (NADH dehydrogenase) and supercomplexes	H+ or Na+ translocating NADH dehydrogenase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth L], B [auth M], C [auth T], D [auth c], G [auth j] A [auth L], B [auth M], C [auth T], D [auth c], G [auth j], H [auth k], I [auth l], J [auth m], K [auth n], L [auth o], M [auth p]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth L], B [auth M], C [auth T], D [auth c], G [auth j] A [auth L], B [auth M], C [auth T], D [auth c], G [auth j], H [auth k], I [auth l], J [auth m], K [auth n], L [auth o], M [auth p]	MemProtMD	Annotated as membrane protein by MemProtMD