8CE3

Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with 3D fragment 2548

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF15024	Glycosyltransferase family 18 (Glyco_transf_18)	Glycosyltransferase family 18	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A	enzyme regulator activity phosphatase inhibitor activity molecular function inhibitor activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity protein phosphatase inhibitor activity enzyme inhibitor activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding enzyme regulator activity phosphatase inhibitor activity molecular function inhibitor activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity protein phosphatase inhibitor activity enzyme inhibitor activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding UDP-glycosyltransferase activity glycosyltransferase activity catalytic activity, acting on a protein catalytic activity, acting on a glycoprotein acetylglucosaminyltransferase activity transferase activity hexosyltransferase activity catalytic activity alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein N-linked glycosylation protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process positive regulation of locomotion regulation of biological process regulation of cell motility regulation of cellular process biological regulation positive regulation of biological process positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process cellular response to stimulus positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction response to stimulus signaling positive regulation of receptor signaling pathway via STAT regulation of signal transduction cell communication positive regulation of response to stimulus signal transduction regulation of signaling cell surface receptor signaling pathway regulation of response to stimulus regulation of cell communication regulation of receptor signaling pathway via STAT positive regulation of signaling viral gene expression viral protein processing viral process protein N-linked glycosylation via asparagine	cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane bounding membrane of organelle organelle membrane extracellular exosome cellular anatomical structure membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm intracellular membrane-bounded organelle endomembrane system Golgi membrane bounding membrane of organelle organelle membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR026116	Glycosyltransferase family 18	Family
A, B	IPR052105	Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Family
A, B	IPR027833	Domain of unknown function DUF4525	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q09328	Liver Cirrhosis, Experimental enterovirus infectious disease attention deficit hyperactivity disorder, inattentive type marginal zone lymphoma pancreatic intraductal papillary-mucinous carcinoma primary biliary cholangitis B-cell chronic lymphocytic leukemia lung cancer osteosarcoma pancreatic intraductal papillary-mucinous neoplasm systemic lupus erythematosus malignant colon neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.