8CO7

Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-09066

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00211	Adenylate and Guanylate cyclase catalytic domain (Guanylate_cyc)	Adenylate and Guanylate cyclase catalytic domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Adenylate cyclase type 10	cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding bicarbonate binding anion binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding bicarbonate binding anion binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding ATPase binding protein binding enzyme binding phosphorus-oxygen lyase activity cyclase activity lyase activity adenylate cyclase activity catalytic activity magnesium ion binding	negative regulation of membrane potential regulation of mitochondrial membrane potential biological regulation negative regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential monosaccharide metabolic process regulation of cellular process catabolic process energy derivation by oxidation of organic compounds positive regulation of biological process carbohydrate catabolic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process negative regulation of membrane potential regulation of mitochondrial membrane potential biological regulation negative regulation of mitochondrial membrane potential regulation of biological quality regulation of membrane potential monosaccharide metabolic process regulation of cellular process catabolic process energy derivation by oxidation of organic compounds positive regulation of biological process carbohydrate catabolic process regulation of generation of precursor metabolites and energy regulation of polysaccharide metabolic process macromolecule catabolic process regulation of primary metabolic process positive regulation of glycogen metabolic process positive regulation of metabolic process glucan metabolic process polysaccharide metabolic process regulation of small molecule metabolic process regulation of glycogen catabolic process glycogen catabolic process small molecule metabolic process positive regulation of macromolecule metabolic process positive regulation of glycogen catabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process positive regulation of cellular process carbohydrate metabolic process regulation of carbohydrate catabolic process regulation of biological process glucan catabolic process glycogen metabolic process primary metabolic process hexose metabolic process generation of precursor metabolites and energy regulation of macromolecule metabolic process regulation of catabolic process positive regulation of catabolic process positive regulation of glucose metabolic process polysaccharide catabolic process metabolic process cellular process energy reserve metabolic process positive regulation of carbohydrate metabolic process macromolecule metabolic process positive regulation of small molecule metabolic process regulation of glycogen metabolic process regulation of metabolic process glucose metabolic process axon extension multicellular organismal process positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization positive regulation of developmental growth system development developmental process regulation of cell projection organization positive regulation of cell development nervous system development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size regulation of mitochondrial depolarization positive regulation of membrane depolarization positive regulation of mitochondrial depolarization mitochondrial depolarization regulation of membrane depolarization membrane depolarization spermatid development spermatid differentiation sexual reproduction spermatogenesis reproductive process multicellular organismal reproductive process cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation germ cell development macroautophagy autophagy regulation of mitophagy regulation of autophagy regulation of macroautophagy mitophagy regulation of autophagy of mitochondrion process utilizing autophagic mechanism autophagy of mitochondrion ribose phosphate metabolic process nucleotide biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process cAMP biosynthetic process cyclic nucleotide metabolic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process cyclic nucleotide biosynthetic process phosphate-containing compound metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process cAMP metabolic process cyclic purine nucleotide metabolic process nucleotide metabolic process nucleobase-containing compound biosynthetic process purine-containing compound metabolic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process muscle hypertrophy regulation of muscle adaptation system process positive regulation of cardiac muscle hypertrophy response to stimulus regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation regulation of response to stimulus positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of phosphate metabolic process purine ribonucleoside triphosphate biosynthetic process positive regulation of nucleotide biosynthetic process regulation of nucleotide biosynthetic process regulation of ATP metabolic process purine nucleoside triphosphate biosynthetic process positive regulation of purine nucleotide biosynthetic process regulation of phosphate metabolic process regulation of nucleotide metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of phosphorus metabolic process regulation of purine nucleotide metabolic process ribonucleoside triphosphate biosynthetic process positive regulation of ATP metabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process ATP metabolic process ATP biosynthetic process positive regulation of nucleotide metabolic process positive regulation of biosynthetic process purine ribonucleoside triphosphate metabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process regulation of biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process positive regulation of purine nucleotide metabolic process positive regulation of ATP biosynthetic process regulation of ATP biosynthetic process cellular response to stimulus positive regulation of cell communication intrinsic apoptotic signaling pathway in response to oxidative stress neuron apoptotic process positive regulation of signal transduction regulation of oxidative stress-induced intrinsic apoptotic signaling pathway signaling regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction intrinsic apoptotic signaling pathway positive regulation of neuron apoptotic process regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of signaling positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of neuron apoptotic process regulation of apoptotic signaling pathway positive regulation of signaling ATP transport nitrogen compound transport organic anion transport nucleotide transport transport purine ribonucleotide transport carbohydrate derivative transport mitochondrial transmembrane transport establishment of localization purine nucleotide transport transmembrane transport adenine nucleotide transport mitochondrial ATP transmembrane transport localization nucleotide transmembrane transport nucleobase-containing compound transport purine-containing compound transmembrane transport organophosphate ester transport mitochondrial transport hexose catabolic process glucose catabolic process monosaccharide catabolic process small molecule catabolic process membrane repolarization regulation of membrane repolarization positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-threonine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification protein metabolic process peptidyl-threonine modification positive regulation of protein phosphorylation protein modification process protein phosphorylation positive regulation of peptidyl-threonine phosphorylation phosphorylation regulation of protein metabolic process macromolecule modification regulation of phosphorylation peptidyl-threonine phosphorylation reactive oxygen species biosynthetic process negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of biological process regulation of reactive oxygen species biosynthetic process negative regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species biosynthetic process negative regulation of biosynthetic process negative regulation of cellular process regulation of reactive oxygen species metabolic process positive regulation of cardiac muscle cell apoptotic process muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process protein localization regulation of localization establishment of protein localization cellular localization regulation of protein localization protein targeting regulation of protein targeting to mitochondrion positive regulation of establishment of protein localization cellular macromolecule localization positive regulation of protein targeting to mitochondrion regulation of establishment of protein localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of protein targeting regulation of cellular localization macromolecule localization protein localization to organelle protein localization to mitochondrion positive regulation of protein localization protein targeting to mitochondrion establishment of protein localization to mitochondrion positive regulation of establishment of protein localization to mitochondrion epithelial cilium movement involved in extracellular fluid movement extracellular transport microtubule-based transport microtubule-based movement microtubule-based process cilium movement neuron projection retraction neuron projection organization positive regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process ossification positive regulation of ossification regulation of ossification positive regulation of smooth muscle cell apoptotic process smooth muscle cell apoptotic process regulation of smooth muscle cell apoptotic process vascular associated smooth muscle cell apoptotic process positive regulation of vascular associated smooth muscle cell apoptotic process regulation of vascular associated smooth muscle cell apoptotic process neuron projection maintenance heart process regulation of actin filament-based process regulation of heart contraction cardiac muscle contraction striated muscle contraction negative regulation of muscle contraction circulatory system process actin filament-based process negative regulation of cardiac muscle contraction blood circulation cardiac muscle cell contraction negative regulation of blood circulation regulation of cardiac muscle contraction actin filament-based movement muscle contraction negative regulation of heart contraction regulation of blood circulation regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction negative regulation of cardiac muscle cell contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction heart contraction negative regulation of multicellular organismal process negative regulation of striated muscle contraction	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol glial cell projection cell projection plasma membrane bounded cell projection astrocyte end-foot astrocyte projection somatodendritic compartment dendrite dendritic tree neuron projection intracellular organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol glial cell projection cell projection plasma membrane bounded cell projection astrocyte end-foot astrocyte projection somatodendritic compartment dendrite dendritic tree neuron projection intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle perinuclear region of cytoplasm cell body neuronal cell body membrane-bounded organelle mitochondrion intracellular membrane-bounded organelle cilium growth cone axon distal axon central region of growth cone site of polarized growth cell periphery apical part of cell membrane plasma membrane plasma membrane region apical plasma membrane basal part of cell extracellular region nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	Domain
A	IPR029787	Nucleotide cyclase	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR016577	Adenylate cyclase, type 10	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q96PN6	hypercalciuria, absorptive, 2 facioscapulohumeral muscular dystrophy Idiopathic hypercalciuria idiopathic inherited hypercalciuria

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.