Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C, E, G
PF22100VtrA C-terminal periplasmic domain (VtrA_C)VtrA C-terminal periplasmic domainVtrA forms a complex with VtrC on the surface of the membrane that surrounds the bacterial cell. These two proteins create a platform that can bind to bile salts and trigger the release of bacterial toxins. This entry represents the C-terminal peripl ...VtrA forms a complex with VtrC on the surface of the membrane that surrounds the bacterial cell. These two proteins create a platform that can bind to bile salts and trigger the release of bacterial toxins. This entry represents the C-terminal periplasmic domain of VtrA that interacts with the VtrC periplasmic domain. The VtrA periplasmic domain adopts an alpha/beta structure consisting of a five-stranded antiparallel beta-sheet and two helices packed on one side of it [1].
Domain
B, D, F, H
PF22280VtrC lipocalin-like domain (VtrC)VtrC lipocalin-like domainThis entry represents a lipocalin-like beta barrel domain found in the Vibrio parahaemolyticus VtrC protein [1]. VtrC, along with VtrA and VtrB, are required for activating the virulence type III secretion system 2 in response to bile salts. The VtrA ...This entry represents a lipocalin-like beta barrel domain found in the Vibrio parahaemolyticus VtrC protein [1]. VtrC, along with VtrA and VtrB, are required for activating the virulence type III secretion system 2 in response to bile salts. The VtrA/VtrC complex activates VtrB in the presence of bile salts. The crystal structure of the periplasmic domains of the VtrA/VtrC heterodimer reveals a beta-barrel with a hydrophobic inner chamber [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E, G
VtrA
B, D, F, H
VtrC -