8EYA

Crystal structure of PTP1B D181A/Q262A/C215A phosphatase domain with a JAK2 activation loop phosphopeptide

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8040614	3000304	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	(Phosphotyrosine protein) phosphatases II	8040614	3000304	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00102	Protein-tyrosine phosphatase (Y_phosphatase)	Protein-tyrosine phosphatase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Tyrosine-protein phosphatase non-receptor type 1	protein binding binding signaling receptor binding insulin receptor binding cell adhesion molecule binding cadherin binding ephrin receptor binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein binding binding signaling receptor binding insulin receptor binding cell adhesion molecule binding cadherin binding ephrin receptor binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity non-membrane spanning protein tyrosine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity phosphatase activity hydrolase activity catalytic activity protein phosphatase binding phosphatase binding protein phosphatase 2A binding RNA binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus negative regulation of cellular process regulation of cell communication cellular process signal transduction cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone growth hormone receptor signaling pathway via JAK-STAT enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus growth hormone receptor signaling pathway cell surface receptor signaling pathway response to endogenous stimulus cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to chemical stimulus response to chemical regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity regulation of MAP kinase activity intracellular signal transduction negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process intracellular signaling cassette negative regulation of protein modification process phosphorus metabolic process protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of MAPK cascade regulation of molecular function regulation of kinase activity negative regulation of protein phosphorylation regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of intracellular signal transduction negative regulation of phosphate metabolic process regulation of intracellular signal transduction negative regulation of protein serine/threonine kinase activity protein metabolic process negative regulation of macromolecule metabolic process negative regulation of molecular function negative regulation of MAP kinase activity regulation of protein kinase activity regulation of macromolecule metabolic process negative regulation of protein kinase activity negative regulation of phosphorus metabolic process MAPK cascade regulation of phosphorylation negative regulation of phosphorylation negative regulation of MAPK cascade regulation of localization import into cell regulation of cellular component organization regulation of transport transport regulation of vesicle-mediated transport establishment of localization vesicle-mediated transport cellular component organization localization cellular component organization or biogenesis endocytosis regulation of endocytosis protein dephosphorylation dephosphorylation platelet-derived growth factor receptor-beta signaling pathway platelet-derived growth factor receptor signaling pathway negative regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cellular response to growth factor stimulus negative regulation of cellular response to growth factor stimulus regulation of vascular endothelial growth factor receptor signaling pathway negative regulation of vascular endothelial growth factor receptor signaling pathway regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway response to growth factor peptidyl-tyrosine dephosphorylation peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity positive regulation of phosphorylation positive regulation of phosphate metabolic process positive regulation of metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of kinase activity regulation of protein tyrosine kinase activity positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of molecular function positive regulation of protein modification process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein kinase activity positive regulation of cellular process positive regulation of transferase activity positive regulation of protein tyrosine kinase activity regulation of peptidyl-tyrosine phosphorylation positive regulation of catalytic activity peptidyl-tyrosine phosphorylation organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization protein localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of establishment of protein localization intracellular transport regulation of protein transport protein transport regulation of cellular localization macromolecule localization regulation of intracellular protein transport intracellular protein transport receptor catabolic process catabolic process macromolecule catabolic process cellular catabolic process receptor metabolic process positive regulation of receptor catabolic process regulation of catabolic process positive regulation of catabolic process regulation of receptor catabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process insulin receptor signaling pathway regulation of cellular response to insulin stimulus regulation of insulin receptor signaling pathway negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway response to insulin cellular response to insulin stimulus positive regulation of IRE1-mediated unfolded protein response positive regulation of cell communication positive regulation of signal transduction regulation of cellular response to stress endoplasmic reticulum unfolded protein response regulation of response to endoplasmic reticulum stress positive regulation of response to stimulus regulation of endoplasmic reticulum unfolded protein response positive regulation of response to endoplasmic reticulum stress cellular response to stress response to stress regulation of response to stress positive regulation of endoplasmic reticulum unfolded protein response response to endoplasmic reticulum stress regulation of IRE1-mediated unfolded protein response cellular response to topologically incorrect protein positive regulation of intracellular signal transduction cellular response to unfolded protein response to unfolded protein response to topologically incorrect protein IRE1-mediated unfolded protein response positive regulation of signaling positive regulation of protein serine/threonine kinase activity positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of JUN kinase activity regulation of JUN kinase activity regulation of hepatocyte growth factor receptor signaling pathway hepatocyte growth factor receptor signaling pathway positive regulation of cellular response to insulin stimulus positive regulation of insulin receptor signaling pathway receptor recycling insulin receptor recycling negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway regulation of programmed cell death intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress regulation of intrinsic apoptotic signaling pathway regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway negative regulation of response to endoplasmic reticulum stress negative regulation of programmed cell death regulation of apoptotic process cell death apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic process apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus regulation of type I interferon-mediated signaling pathway response to cytokine response to biotic stimulus cytokine-mediated signaling pathway interferon-mediated signaling pathway cellular response to type I interferon innate immune response regulation of immune system process cellular response to cytokine stimulus response to external biotic stimulus immune response response to other organism defense response regulation of innate immune response regulation of cytokine-mediated signaling pathway defense response to symbiont response to external stimulus response to peptide regulation of response to cytokine stimulus immune system process defense response to other organism type I interferon-mediated signaling pathway regulation of immune response response to type I interferon PERK-mediated unfolded protein response integrated stress response signaling ER-nucleus signaling pathway negative regulation of endoplasmic reticulum unfolded protein response regulation of PERK-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle organelle subcompartment cytoplasmic side of membrane membrane intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle organelle subcompartment cytoplasmic side of membrane membrane intracellular membrane-bounded organelle endomembrane system side of membrane endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasmic side of endoplasmic reticulum membrane organelle membrane endoplasmic reticulum membrane sorting endosome endosome intracellular vesicle cytoplasmic vesicle vesicle mitochondrial membrane organelle inner membrane mitochondrion mitochondrial inner membrane organelle envelope mitochondrial envelope mitochondrial crista protein-containing complex early endosome membrane-enclosed lumen intracellular organelle lumen organelle lumen endosome lumen mitochondrial matrix
C [auth D], D [auth E]	Tyrosine-protein kinase JAK2 activation loop phosphopeptide	protein binding binding histone binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding protein binding binding histone binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding non-membrane spanning protein tyrosine kinase activity cation binding metal ion binding angiotensin receptor binding signaling receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding kinase binding enzyme binding protein kinase binding tetrapyrrole binding heme binding insulin receptor substrate binding interleukin-12 receptor binding cytokine receptor binding growth factor receptor binding histone H3Y41 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity phosphatidylinositol 3-kinase binding peptide hormone receptor binding hormone receptor binding identical protein binding SH2 domain binding protein domain specific binding growth hormone receptor binding acetylcholine receptor binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling cell surface receptor signaling pathway via STAT peptidyl-tyrosine modification peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process tyrosine phosphorylation of STAT protein protein phosphorylation phosphorylation cellular metabolic process primary metabolic process macromolecule modification macromolecule metabolic process peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion response to chemical response to antibiotic response to cytokine cellular response to interleukin-12 cytokine-mediated signaling pathway response to peptide response to interleukin-12 cellular response to cytokine stimulus interleukin-12-mediated signaling pathway negative regulation of biological process negative regulation of cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway post-translational protein modification biological process involved in interspecies interaction between organisms response to type II interferon cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway response to stress innate immune response response to external biotic stimulus immune response response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus immune system process defense response to other organism intracellular receptor signaling pathway response to lipid hormone-mediated signaling pathway nuclear receptor-mediated mineralocorticoid signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound nuclear receptor-mediated corticosteroid signaling pathway cellular response to chemical stimulus cellular response to lipid nuclear receptor-mediated signaling pathway interleukin-5-mediated signaling pathway negative regulation of cardiac muscle cell apoptotic process muscle cell apoptotic process negative regulation of programmed cell death regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process cardiac muscle cell apoptotic process negative regulation of apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process negative regulation of muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process collagen-activated signaling pathway multicellular organismal process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation regulation of multicellular organismal process T cell proliferation regulation of lymphocyte proliferation cell activation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation interleukin-35-mediated signaling pathway myeloid leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation inflammatory response glial cell activation neuroinflammatory response regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of molecular function regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis interleukin-23-mediated signaling pathway protein polymerization actin polymerization or depolymerization actin filament polymerization actin cytoskeleton organization protein-containing complex organization actin filament organization cellular component organization cellular component biogenesis organelle organization cellular component assembly protein-containing complex assembly actin filament-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process cytokine production regulation of cytokine production interleukin-17 production regulation of cellular metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression regulation of interleukin-17 production positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of interleukin-17 production positive regulation of cytokine production positive regulation of cellular biosynthetic process regulation of MHC class II biosynthetic process MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process G protein-coupled receptor signaling pathway regulation of body fluid levels positive regulation of platelet activation coagulation regulation of biological quality response to wounding wound healing hemostasis blood coagulation regulation of platelet activation platelet activation positive regulation of phosphorylation positive regulation of receptor signaling pathway via STAT regulation of transferase activity positive regulation of phosphate metabolic process regulation of phosphate metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of protein modification process positive regulation of protein kinase activity activation of Janus kinase activity positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production interleukin-3-mediated signaling pathway response to oxygen-containing compound response to lipopolysaccharide response to bacterium response to molecule of bacterial origin regulation of type II interferon production type II interferon production positive regulation of type II interferon production response to amine response to nitrogen compound regulation of NK T cell proliferation positive regulation of NK T cell proliferation regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation alpha-beta T cell activation NK T cell proliferation positive regulation of alpha-beta T cell activation positive regulation of NK T cell activation regulation of alpha-beta T cell proliferation regulation of NK T cell activation NK T cell activation cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway cellular response to peptide hormone stimulus cellular response to oxygen-containing compound response to growth hormone positive regulation of epithelial cell apoptotic process regulation of epithelial cell apoptotic process epithelial cell apoptotic process adaptive immune response developmental process anatomical structure development tissue development mesoderm development epithelium development mammary gland epithelium development mammary gland development gland development animal organ development extrinsic apoptotic signaling pathway regulation of developmental process cellular developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation cell differentiation homotypic cell-cell adhesion regulation of homotypic cell-cell adhesion platelet aggregation regulation of platelet aggregation positive regulation of homotypic cell-cell adhesion positive regulation of platelet aggregation response to ketone cellular response to ketone cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone protein localization regulation of localization cellular localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization positive regulation of transport establishment of protein localization to organelle regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production protein autophosphorylation trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling positive regulation of signaling receptor activity regulation of signaling receptor activity cellular response to interleukin-3 response to interleukin-3 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor homeostatic process hemopoiesis cell development erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis granulocyte-macrophage colony-stimulating factor signaling pathway positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of growth hormone receptor signaling pathway positive regulation of growth hormone receptor signaling pathway positive regulation of cytosolic calcium ion concentration erythropoietin-mediated signaling pathway response to erythropoietin cellular response to erythropoietin adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T-helper 17 type immune response regulation of adaptive immune response positive regulation of T-helper 17 type immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response regulation of immune response positive regulation of adaptive immune response T-helper 17 type immune response regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation symbiont-induced defense-related programmed cell death cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to biotic stimulus skeletal muscle satellite cell proliferation positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of skeletal muscle cell proliferation positive regulation of skeletal muscle satellite cell proliferation regulation of skeletal muscle satellite cell proliferation skeletal muscle cell proliferation regulation of skeletal muscle cell proliferation striated muscle cell proliferation positive regulation of natural killer cell proliferation regulation of natural killer cell activation positive regulation of natural killer cell activation natural killer cell activation natural killer cell proliferation regulation of natural killer cell proliferation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of postsynapse to nucleus signaling pathway postsynaptic signal transduction postsynapse to nucleus signaling pathway neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process adaptive thermogenesis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade regulation of defense response regulation of response to external stimulus regulation of inflammatory response regulation of response to stress multicellular organism development post-embryonic development post-embryonic hemopoiesis negative regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein cell projection organization neuron projection development regeneration response to axon injury neuron projection regeneration neurogenesis axon regeneration neuron differentiation cellular response to stress system development plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development response to oxidative stress response to hydroperoxide regulation of DNA binding regulation of binding negative regulation of binding negative regulation of molecular function negative regulation of DNA binding positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion regulation of hormone secretion regulation of peptide secretion positive regulation of secretion by cell hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion secretion regulation of peptide transport export from cell positive regulation of protein secretion peptide transport regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion intrinsic apoptotic signaling pathway in response to oxidative stress intrinsic apoptotic signaling pathway cellular response to virus response to virus	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane anchoring junction intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane anchoring junction cell junction focal adhesion cell-substrate junction membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola intracellular organelle organelle euchromatin intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle protein-containing complex plasma membrane protein complex interleukin-23 receptor complex plasma membrane signaling receptor complex membrane protein complex receptor complex synapse glutamatergic synapse cytoskeleton interleukin-12 receptor complex postsynapse membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen granulocyte macrophage colony-stimulating factor receptor complex endosome intracellular vesicle endomembrane system cytoplasmic vesicle endosome lumen vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B	IPR051985	Non-receptor type tyrosine-specific phosphatase	Family
A, B	IPR012265	Protein-tyrosine phosphatase, non-receptor type-1/2	Family
A, B	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A, B	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A, B	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
C [auth D], D [auth E]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
C [auth D], D [auth E]	IPR000719	Protein kinase domain	Domain
C [auth D], D [auth E]	IPR041381	JAK1-3/TYK2, pleckstrin homology-like domain	Domain
C [auth D], D [auth E]	IPR017441	Protein kinase, ATP binding site	Binding Site
C [auth D], D [auth E]	IPR036860	SH2 domain superfamily	Homologous Superfamily
C [auth D], D [auth E]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
C [auth D], D [auth E]	IPR051286	Janus Kinase (JAK)	Family
C [auth D], D [auth E]	IPR041046	JAK, FERM F2 lobe domain	Domain
C [auth D], D [auth E]	IPR019749	Band 4.1 domain	Domain
C [auth D], D [auth E]	IPR020693	Tyrosine-protein kinase, non-receptor Jak2	Family
C [auth D], D [auth E]	IPR035860	Tyrosine-protein kinase JAK2, SH2 domain	Domain
C [auth D], D [auth E]	IPR037838	JAK2, FERM domain C-lobe	Domain
C [auth D], D [auth E]	IPR000299	FERM domain	Domain
C [auth D], D [auth E]	IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2	Family
C [auth D], D [auth E]	IPR008266	Tyrosine-protein kinase, active site	Active Site
C [auth D], D [auth E]	IPR019748	FERM central domain	Domain
C [auth D], D [auth E]	IPR035963	FERM superfamily, second domain	Homologous Superfamily
C [auth D], D [auth E]	IPR000980	SH2 domain	Domain
C [auth D], D [auth E]	IPR011993	PH-like domain superfamily	Homologous Superfamily
C [auth D], D [auth E]	IPR035588	Janus kinase 2, pseudokinase domain	Domain
C [auth D], D [auth E]	IPR035589	Janus kinase 2, catalytic domain	Domain
C [auth D], D [auth E]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C [auth D], D [auth E]	IPR041155	FERM F1 lobe ubiquitin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P18031	type 2 diabetes mellitus Insulin Resistance Rett syndrome obesity disorder hypertensive disorder hyperinsulinism B-cell neoplasm Hodgkins lymphoma lung cancer maturity-onset diabetes of the young colorectal adenoma ovarian cancer schizophrenia Hodgkin's lymphoma, mixed cellularity Huntington disease type 2 diabetes mellitus Insulin Resistance Rett syndrome obesity disorder hypertensive disorder hyperinsulinism B-cell neoplasm Hodgkins lymphoma lung cancer maturity-onset diabetes of the young colorectal adenoma ovarian cancer schizophrenia Hodgkin's lymphoma, mixed cellularity Huntington disease inborn carbohydrate metabolic disorder mediastinal cancer nodular lymphocyte predominant Hodgkin lymphoma colorectal cancer Hodgkin's lymphoma, lymphocytic depletion sarcoidosis vitiligo Hodgkin's lymphoma, lymphocytic-histiocytic predominance
C [auth D], D [auth E]	Pharos: O60674	acquired polycythemia vera ulcerative colitis primary myelofibrosis essential thrombocythemia acute myeloid leukemia polycythemia thrombocytosis disease Venous Thrombosis hepatic vein thrombosis leukemia bone marrow neoplasm myelofibrosis thrombocythemia 3 Budd-Chiari syndrome mesenteric vascular occlusion acquired polycythemia vera ulcerative colitis primary myelofibrosis essential thrombocythemia acute myeloid leukemia polycythemia thrombocytosis disease Venous Thrombosis hepatic vein thrombosis leukemia bone marrow neoplasm myelofibrosis thrombocythemia 3 Budd-Chiari syndrome mesenteric vascular occlusion non-alcoholic fatty liver disease familial thrombocytosis cancer Crohn disease heart valve disease cervical cancer familial polycythemia prostate cancer systemic lupus erythematosus calcinosis coronary artery disease myeloproliferative neoplasm eosinophilic esophagitis ovarian cancer primary familial polycythemia due to EPO receptor mutation atopic eczema Sjogren syndrome thrombocythemia 1 malignant mesothelioma transitional cell carcinoma chronic myelogenous leukemia, BCR-ABL1 positive myocardial ischemia ovarian serous adenocarcinoma aleukemic leukemia inflammatory bowel disease psoriatic arthritis autoimmune disease lung disease tuberculosis congenital anemia cystic fibrosis neoplasm diffuse large B-cell lymphoma osteosarcoma placenta disease hematopoietic and lymphoid system neoplasm anemia large cell medulloblastoma rheumatoid arthritis bone marrow disease lymphatic system disease thrombotic disease