Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamily(Phosphotyrosine protein) phosphatases II 8040614 3000304 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00102Protein-tyrosine phosphatase (Y_phosphatase)Protein-tyrosine phosphatase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Tyrosine-protein phosphatase non-receptor type 1
B [auth C]Non-receptor tyrosine-protein kinase TYK2 activation loop phosphopeptide

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR016130Protein-tyrosine phosphatase, active siteActive Site
IPR051985Non-receptor type tyrosine-specific phosphataseFamily
IPR012265Protein-tyrosine phosphatase, non-receptor type-1/2Family
IPR003595Protein-tyrosine phosphatase, catalyticDomain
IPR029021Protein-tyrosine phosphatase-likeHomologous Superfamily
IPR000242Tyrosine-specific protein phosphatase, PTPase domainDomain
IPR000387Tyrosine-specific protein phosphatases domainDomain
B [auth C]IPR000299FERM domainDomain
B [auth C]IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2Family
B [auth C]IPR008266Tyrosine-protein kinase, active siteActive Site
B [auth C]IPR020635Tyrosine-protein kinase, catalytic domainDomain
B [auth C]IPR000719Protein kinase domainDomain
B [auth C]IPR035963FERM superfamily, second domainHomologous Superfamily
B [auth C]IPR041381JAK1-3/TYK2, pleckstrin homology-like domainDomain
B [auth C]IPR017441Protein kinase, ATP binding siteBinding Site
B [auth C]IPR036860SH2 domain superfamilyHomologous Superfamily
B [auth C]IPR000980SH2 domainDomain
B [auth C]IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
B [auth C]IPR016045Tyrosine-protein kinase, non-receptor, TYK2, N-terminalDomain
B [auth C]IPR051286Janus Kinase (JAK)Family
B [auth C]IPR041046JAK, FERM F2 lobe domainDomain
B [auth C]IPR019749Band 4.1 domainDomain
B [auth C]IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
B [auth C]IPR041155FERM F1 lobe ubiquitin-like domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP18031
B [auth C]PharosP29597

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
B [auth C]PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048