Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B Superfamily(Phosphotyrosine protein) phosphatases II 8040614 3000304 SCOP2B (2022-06-29)
BSCOP2B Superfamily(Phosphotyrosine protein) phosphatases II 8040614 3000304 SCOP2B (2022-06-29)
CSCOP2B Superfamily(Phosphotyrosine protein) phosphatases II 8040614 3000304 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C
PF00102Protein-tyrosine phosphatase (Y_phosphatase)Protein-tyrosine phosphatase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C
Tyrosine-protein phosphatase non-receptor type 1
D [auth E],
E [auth F],
F [auth G]
Tyrosine-protein kinase JAK2

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C
IPR016130Protein-tyrosine phosphatase, active siteActive Site
A, B, C
IPR051985Non-receptor type tyrosine-specific phosphataseFamily
A, B, C
IPR012265Protein-tyrosine phosphatase, non-receptor type-1/2Family
A, B, C
IPR003595Protein-tyrosine phosphatase, catalyticDomain
A, B, C
IPR029021Protein-tyrosine phosphatase-likeHomologous Superfamily
A, B, C
IPR000242Tyrosine-specific protein phosphatase, PTPase domainDomain
A, B, C
IPR000387Tyrosine-specific protein phosphatases domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR020635Tyrosine-protein kinase, catalytic domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR000719Protein kinase domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR041381JAK1-3/TYK2, pleckstrin homology-like domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR017441Protein kinase, ATP binding siteBinding Site
D [auth E],
E [auth F],
F [auth G]
IPR036860SH2 domain superfamilyHomologous Superfamily
D [auth E],
E [auth F],
F [auth G]
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR051286Janus Kinase (JAK)Family
D [auth E],
E [auth F],
F [auth G]
IPR041046JAK, FERM F2 lobe domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR019749Band 4.1 domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR020693Tyrosine-protein kinase, non-receptor Jak2Family
D [auth E],
E [auth F],
F [auth G]
IPR035860Tyrosine-protein kinase JAK2, SH2 domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR037838JAK2, FERM domain C-lobeDomain
D [auth E],
E [auth F],
F [auth G]
IPR000299FERM domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR016251Tyrosine-protein kinase, non-receptor Jak/Tyk2Family
D [auth E],
E [auth F],
F [auth G]
IPR008266Tyrosine-protein kinase, active siteActive Site
D [auth E],
E [auth F],
F [auth G]
IPR019748FERM central domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR035963FERM superfamily, second domainHomologous Superfamily
D [auth E],
E [auth F],
F [auth G]
IPR000980SH2 domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR011993PH-like domain superfamilyHomologous Superfamily
D [auth E],
E [auth F],
F [auth G]
IPR035588Janus kinase 2, pseudokinase domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR035589Janus kinase 2, catalytic domainDomain
D [auth E],
E [auth F],
F [auth G]
IPR011009Protein kinase-like domain superfamilyHomologous Superfamily
D [auth E],
E [auth F],
F [auth G]
IPR041155FERM F1 lobe ubiquitin-like domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C
PharosP18031
D [auth E],
E [auth F],
F [auth G]
PharosO60674

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
D [auth E],
E [auth F],
F [auth G]
PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048