8FW0

MtrR from Neisseria gonorrhoeae bound to beta-Estradiol

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyHomeodomain-like 8090167 3000001 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyTetR C-terminal domain-like 8090168 3000086 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyTetR C-terminal domain-like 8090168 3000086 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyHomeodomain-like 8090167 3000001 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyTetR C-terminal domain-like 8090168 3000086 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyHomeodomain-like 8090167 3000001 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyHomeodomain-like 8090167 3000001 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyTetR C-terminal domain-like 8090168 3000086 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF08361MAATS-type transcriptional repressor, C-terminal region (TetR_C_2)MAATS-type transcriptional repressor, C-terminal regionThis domain is named after the various transcriptional regulatory proteins that it contains, including MtrR (Swiss:Q6RV06), AcrR (Swiss:P34000), ArpR (Swiss:Q9KJC4), TtgR (Swiss:Q9AIU0) and SmeT (Swiss:Q8KLP4). These are members of the TetR family of ...This domain is named after the various transcriptional regulatory proteins that it contains, including MtrR (Swiss:Q6RV06), AcrR (Swiss:P34000), ArpR (Swiss:Q9KJC4), TtgR (Swiss:Q9AIU0) and SmeT (Swiss:Q8KLP4). These are members of the TetR family of transcriptional repressors, that are involved in the control of expression of multidrug resistance proteins [1,2,3]. This domain binds multiple drugs, antibiotics, flavonoids and indole (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Domain
A, B, C, D
PF00440Bacterial regulatory proteins, tetR family (TetR_N)Bacterial regulatory proteins, tetR family- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
HTH-type transcriptional regulator MtrR - -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D
IPR023772DNA-binding HTH domain, TetR-type, conserved siteConserved Site
A, B, C, D
IPR009057Homedomain-like superfamilyHomologous Superfamily
A, B, C, D
IPR050624HTH-type Transcriptional RegulatorFamily
A, B, C, D
IPR001647DNA-binding HTH domain, TetR-typeDomain
A, B, C, D
IPR013572Transcription regulator MAATS, C-terminalDomain
A, B, C, D
IPR036271Tetracyclin repressor-like, C-terminal domain superfamilyHomologous Superfamily