8G9D

Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 5- phosphonodifluoroacetamide inositol pentakisphosphate (5-PCF2Am-InsP5), an analogue of 5-InsP7

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Nudix	8041411	3000098	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00293	NUDIX domain (NUDIX)	NUDIX domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Diphosphoinositol polyphosphate phosphohydrolase 1	pyrophosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity bis(5'-adenosyl)-hexaphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity cation binding manganese ion binding pyrophosphatase activity inositol diphosphate tetrakisphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity diphosphoinositol-polyphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity bis(5'-adenosyl)-hexaphosphatase activity inositol bisdiphosphate tetrakisphosphate diphosphatase activity inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity inositol diphosphate pentakisphosphate diphosphatase activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding bis(5'-adenosyl)-pentaphosphatase activity magnesium ion binding endopolyphosphatase activity zinc ion binding 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase activity 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	nucleoside phosphate metabolic process catabolic process organophosphate catabolic process primary metabolic process diadenosine polyphosphate metabolic process nucleoside phosphate catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process diadenosine hexaphosphate metabolic process organophosphate metabolic process diadenosine polyphosphate catabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process nucleoside phosphate metabolic process catabolic process organophosphate catabolic process primary metabolic process diadenosine polyphosphate metabolic process nucleoside phosphate catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process diadenosine hexaphosphate metabolic process organophosphate metabolic process diadenosine polyphosphate catabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process cellular process small molecule metabolic process phosphorus metabolic process nucleotide catabolic process diadenosine hexaphosphate catabolic process regulation of biological process signaling biological regulation cell-cell signaling cell communication polyol metabolic process alcohol catabolic process organic hydroxy compound metabolic process polyol catabolic process alcohol metabolic process inositol phosphate metabolic process diphosphoinositol polyphosphate metabolic process organic hydroxy compound catabolic process diphosphoinositol polyphosphate catabolic process inositol phosphate catabolic process small molecule catabolic process diadenosine pentaphosphate metabolic process diadenosine pentaphosphate catabolic process RNA metabolic process macromolecule metabolic process nucleic acid metabolic process RNA decapping ribose phosphate metabolic process ribonucleotide catabolic process carbohydrate derivative metabolic process purine nucleotide metabolic process ribonucleotide metabolic process purine ribonucleotide catabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process adenosine 5'-(hexahydrogen pentaphosphate) catabolic process purine-containing compound catabolic process purine-containing compound metabolic process adenosine 5'-(hexahydrogen pentaphosphate) metabolic process purine ribonucleotide metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015797	NUDIX hydrolase-like domain superfamily	Homologous Superfamily
A	IPR047198	Diphosphoinositol polyphosphate phosphohydrolase-like, NUDIX domain	Domain
A	IPR000086	NUDIX hydrolase domain	Domain
A	IPR020084	NUDIX hydrolase, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95989	atrial fibrillation glioblastoma lung cancer metabolic syndrome X osteosarcoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor invasive ductal breast carcinoma malignant glioma neoplasm ovarian cancer rheumatoid arthritis breast cancer large cell medulloblastoma medulloblastoma atrial fibrillation glioblastoma lung cancer metabolic syndrome X osteosarcoma pancreatic intraductal papillary-mucinous neoplasm atypical teratoid rhabdoid tumor invasive ductal breast carcinoma malignant glioma neoplasm ovarian cancer rheumatoid arthritis breast cancer large cell medulloblastoma medulloblastoma non-alcoholic fatty liver disease pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.