Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPLP-dependent transferases 8086500 3000954 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPLP-dependent transferases 8086500 3000954 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyPLP-dependent transferases 8086500 3000954 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyPLP-dependent transferases 8086500 3000954 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AF_UNCLASSIFIEDe8g9zA1 A: a+b two layersX: C-terminal domain in some PLP-dependent transferases (From Topology)H: C-terminal domain in some PLP-dependent transferases (From Topology)T: C-terminal domain in some PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)
AF_UNCLASSIFIEDe8g9zA2 A: a/b three-layered sandwichesX: PLP-dependent transferases (From Topology)H: PLP-dependent transferases (From Topology)T: PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)
BF_UNCLASSIFIEDe8g9zB1 A: a+b two layersX: C-terminal domain in some PLP-dependent transferases (From Topology)H: C-terminal domain in some PLP-dependent transferases (From Topology)T: C-terminal domain in some PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)
BF_UNCLASSIFIEDe8g9zB2 A: a/b three-layered sandwichesX: PLP-dependent transferases (From Topology)H: PLP-dependent transferases (From Topology)T: PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)
CF_UNCLASSIFIEDe8g9zC1 A: a+b two layersX: C-terminal domain in some PLP-dependent transferases (From Topology)H: C-terminal domain in some PLP-dependent transferases (From Topology)T: C-terminal domain in some PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)
CF_UNCLASSIFIEDe8g9zC2 A: a/b three-layered sandwichesX: PLP-dependent transferases (From Topology)H: PLP-dependent transferases (From Topology)T: PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)
DF_UNCLASSIFIEDe8g9zD1 A: a+b two layersX: C-terminal domain in some PLP-dependent transferases (From Topology)H: C-terminal domain in some PLP-dependent transferases (From Topology)T: C-terminal domain in some PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)
DF_UNCLASSIFIEDe8g9zD2 A: a/b three-layered sandwichesX: PLP-dependent transferases (From Topology)H: PLP-dependent transferases (From Topology)T: PLP-dependent transferasesF: F_UNCLASSIFIEDECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF05889O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS (SepSecS)O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecSEarly annotation suggested this family, SepSecS, of several eukaryotic and archaeal proteins, was involved in antigen-antibodies responses in the liver and pancreas [1,2]. Structural studies show that the family is O-phosphoseryl-tRNA(Sec) selenium t ...Early annotation suggested this family, SepSecS, of several eukaryotic and archaeal proteins, was involved in antigen-antibodies responses in the liver and pancreas [1,2]. Structural studies show that the family is O-phosphoseryl-tRNA(Sec) selenium transferase, an enzyme involved in the synthesis of the amino acid selenocysteine (Sec). Sec is the only amino acid whose biosynthesis occurs on its cognate transfer RNA (tRNA). SepSecS catalyses the final step in the formation of the amino acid [3,4,5,6]. The early observation that autoantibodies isolated from patients with type I autoimmune hepatitis targeted a ribonucleoprotein complex containing tRNASec led to the identification and characterisation of the archaeal and the human SepSecS [2]. SepSecS forms its own branch in the family of fold-type I pyridoxal phosphate (PLP) enzymes that goes back to the last universal common ancestor which explains why the archaeal sequences Swiss:Q8TXK0 and Swiss:Q8TYR3 are annotated as being pyridoxal phosphate-dependent enzymes.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
O-phosphoseryl-tRNA(Sec) selenium transferase
RNA (90-MER)---