Annotations: 8GDN

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	NAD-binding domain of HMG-CoA reductase	8040282	3001200	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	NAD-binding domain of HMG-CoA reductase	8040282	3001200	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Substrate-binding domain of HMG-CoA reductase	8040285	3001471	SCOP2B (2022-06-29)

Chains	Accession	Name	Description	Comments	Source
A, B	PF00368	Hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA_red)	Hydroxymethylglutaryl-coenzyme A reductase	-	Family

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	3-hydroxy-3-methylglutaryl-coenzyme A reductase	oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors hydroxymethylglutaryl-CoA reductase (NADPH) activity catalytic activity hydroxymethylglutaryl-CoA reductase (NADH) activity	nucleoside phosphate metabolic process cellular metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process sulfur compound metabolic process cellular process small molecule metabolic process amide metabolic process phosphorus metabolic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process purine-containing compound metabolic process nucleobase-containing compound metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process metabolic process sulfur compound metabolic process cellular process small molecule metabolic process amide metabolic process phosphorus metabolic process coenzyme A metabolic process	-

Chains	Accession	Name	Type
A, B	IPR009029	Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily	Homologous Superfamily
A, B	IPR023074	Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily	Homologous Superfamily
A, B	IPR009023	Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily	Homologous Superfamily
A, B	IPR002202	Hydroxymethylglutaryl-CoA reductase, class I/II	Family
A, B	IPR004553	Hydroxymethylglutaryl-CoA reductase, bacterial-type	Family
A, B	IPR023076	Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site	Conserved Site