8Q6R

Structure of complement FP in complex with the TPP-3077 VHH

External Resource: Annotation

IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A, B	VHH TPP-3077, anti-properdin	VH	Homo sapiens (human), Lama glama (llama)	IGHV3S301, IGHJ501	V-DOMAIN VH	IG	V-KAPPA-VH-C-KAPPA-CH1	IMGT (202444-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A, B	Heavy Chain	IGHV3	-	properdin	SAbDab (2024-11-08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, E	PF00090	Thrombospondin type 1 domain (TSP_1)	Thrombospondin type 1 domain	-	Domain
C, E	PF18487	Thrombospondin type 1 repeat (TSR)	Thrombospondin type 1 repeat	-	Repeat
D, F	PF00090	Thrombospondin type 1 domain (TSP_1)	Thrombospondin type 1 domain	-	Domain
D, F	PF22195	CFP-like, C-terminal thrombospondin type 1 domain (CFP_C_TSP1)	CFP-like, C-terminal thrombospondin type 1 domain	This domain is found at the C-terminal end of human Properdin (CFP, for Complement factor P) and similar animal proteins. CFP is a positive regulator of the alternate pathway (AP) of complement. It contains six thrombospondin repeat type I (TSP 1-6 d ...	This domain is found at the C-terminal end of human Properdin (CFP, for Complement factor P) and similar animal proteins. CFP is a positive regulator of the alternate pathway (AP) of complement. It contains six thrombospondin repeat type I (TSP 1-6 domains and an N-terminal domain (Pfam:PF18487). This entry represents the last TSP type I domain, which binds to the first TSP type I domain (Pfam:PF00090), contributing to multimerisation [1-5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	The properdin specific VHH TPP-3077	-	-	-
C, E	Properdin	-	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of localization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization transport vesicle-mediated transport cellular component organization opsonization localization positive regulation of endocytosis positive regulation of immune effector process phagocytosis cell recognition cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of opsonization regulation of opsonization immune effector process phagocytosis, recognition positive regulation of phagocytosis positive regulation of transport cellular process endocytosis humoral immune response biological process involved in interspecies interaction between organisms complement activation, alternative pathway response to biotic stimulus complement activation response to stress innate immune response response to external biotic stimulus response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism activation of immune response defense response to bacterium response to bacterium	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle endoplasmic reticulum lumen endoplasmic reticulum extracellular region Golgi membrane Golgi apparatus cytoplasmic side of membrane membrane cytoplasmic side of Golgi membrane side of membrane bounding membrane of organelle organelle membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule extracellular space
D, F	Properdin	-	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process regulation of immune effector process import into cell regulation of localization regulation of cellular process positive regulation of cellular component organization regulation of cellular component organization transport vesicle-mediated transport cellular component organization opsonization localization positive regulation of endocytosis positive regulation of immune effector process phagocytosis cell recognition cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of opsonization regulation of opsonization immune effector process phagocytosis, recognition positive regulation of phagocytosis positive regulation of transport cellular process endocytosis humoral immune response biological process involved in interspecies interaction between organisms complement activation, alternative pathway response to biotic stimulus complement activation response to stress innate immune response response to external biotic stimulus response to other organism defense response defense response to symbiont response to external stimulus defense response to other organism activation of immune response defense response to bacterium response to bacterium	membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure tertiary granule lumen membrane-enclosed lumen intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen tertiary granule intracellular organelle organelle lumen cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle endoplasmic reticulum lumen endoplasmic reticulum extracellular region Golgi membrane Golgi apparatus cytoplasmic side of membrane membrane cytoplasmic side of Golgi membrane side of membrane bounding membrane of organelle organelle membrane vesicle lumen cytoplasmic vesicle lumen secretory granule lumen specific granule lumen specific granule extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, E	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
C, E	IPR052065	Complement and asymmetry regulator	Family
C, E	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
C, E	IPR054019	Properdin, thrombospondin type 1 C-terminal	Repeat
C, E	IPR049536	Properdin, thrombospondin type 1 repeat 0	Repeat
D, F	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
D, F	IPR052065	Complement and asymmetry regulator	Family
D, F	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
D, F	IPR054019	Properdin, thrombospondin type 1 C-terminal	Repeat
D, F	IPR049536	Properdin, thrombospondin type 1 repeat 0	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, E	Pharos: P27918	properdin deficiency, X-linked meningococcal meningitis Liver Cirrhosis, Experimental atypical hemolytic-uremic syndrome intellectual disability lung adenocarcinoma MALT lymphoma B-cell chronic lymphocytic leukemia interstitial cystitis lung cancer non-small cell lung carcinoma hepatocellular carcinoma osteosarcoma
D, F	Pharos: P27918	properdin deficiency, X-linked meningococcal meningitis Liver Cirrhosis, Experimental atypical hemolytic-uremic syndrome intellectual disability lung adenocarcinoma MALT lymphoma B-cell chronic lymphocytic leukemia interstitial cystitis lung cancer non-small cell lung carcinoma hepatocellular carcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.