9AY7

Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyProtein kinase-like (PK-like) 8069273 3000066 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyProtein kinase-like (PK-like) 8042320 3000066 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain
PF00069Protein kinase domain (Pkinase)Protein kinase domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
RAF proto-oncogene serine/threonine-protein kinase
Dual specificity mitogen-activated protein kinase kinase 1

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP04049
PharosQ02750