Annotations: 9B4R

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ras-related protein M-Ras	guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding guanyl nucleotide binding binding nucleotide binding GDP binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GTP-dependent protein binding protein binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GTP binding purine ribonucleoside triphosphate binding	cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis cytoskeleton organization response to peptide response to stimulus response to chemical response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular process cellular component organization or biogenesis cytoskeleton organization response to peptide response to stimulus response to chemical response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor cellular response to stimulus regulation of biological process small GTPase-mediated signal transduction regulation of cellular process signaling Ras protein signal transduction biological regulation intracellular signal transduction cell communication intracellular signaling cassette signal transduction	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005225	Small GTP-binding domain	Domain
A	IPR020849	Small GTPase, Ras-type	Family
A	IPR001806	Small GTPase	Family
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O14807	carotid artery disease coronary artery disease malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma atypical teratoid rhabdoid tumor Carotid Atherosclerosis Hodgkins lymphoma large cell medulloblastoma malignant glioma myocardial infarction pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor carotid artery disease coronary artery disease malignant ependymoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia adrenal cortex carcinoma atypical teratoid rhabdoid tumor Carotid Atherosclerosis Hodgkins lymphoma large cell medulloblastoma malignant glioma myocardial infarction pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor amyotrophic lateral sclerosis breast cancer glioblastoma lung carcinoma malignant mesothelioma myopathy pancreatic intraductal papillary-mucinous neoplasm type 2 diabetes mellitus ductal breast carcinoma in situ heart disease invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.