9BCJ

Crystal structure of human hemoglobin in complex with the HbpA receptor from Corynebacterium diphtheriae

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00042	Globin (Globin)	Globin	-	Domain
B	PF00042	Globin (Globin)	Globin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Hemoglobin subunit alpha	oxygen binding binding small molecule binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding organic acid binding	catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport carbon dioxide transport nitric oxide transport catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process hydrogen peroxide catabolic process oxygen transport localization transport gas transport establishment of localization one-carbon compound transport carbon dioxide transport nitric oxide transport nitrogen compound transport response to hydrogen peroxide response to oxidative stress response to stimulus response to stress response to chemical response to oxygen-containing compound response to reactive oxygen species cellular response to stimulus cellular detoxification cellular response to chemical stimulus detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle blood microparticle intracellular vesicle membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen endocytic vesicle lumen endocytic vesicle
B	Hemoglobin subunit beta	hemoglobin binding protein binding binding oxygen binding small molecule binding hemoglobin alpha binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding organic acid binding cation binding ion binding hemoglobin binding protein binding binding oxygen binding small molecule binding hemoglobin alpha binding oxygen carrier activity molecular carrier activity organic cyclic compound binding tetrapyrrole binding heme binding organic acid binding cation binding ion binding metal ion binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process catabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process hydrogen peroxide catabolic process multicellular organismal process system process circulatory system process regulation of blood pressure regulation of biological quality blood circulation regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation response to wounding platelet activation oxygen transport localization transport gas transport establishment of localization one-carbon compound transport carbon dioxide transport renal system process renal absorption nitric oxide transport nitrogen compound transport regulation of tube diameter regulation of tube size vascular process in circulatory system blood vessel diameter maintenance regulation of anatomical structure size response to hydrogen peroxide response to oxidative stress response to chemical response to oxygen-containing compound response to reactive oxygen species cellular response to stimulus cellular detoxification cellular response to chemical stimulus detoxification cellular oxidant detoxification cellular response to toxic substance response to toxic substance	protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space protein-containing complex cellular anatomical structure intracellular anatomical structure hemoglobin complex cytoplasm cytosol haptoglobin-hemoglobin complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle membrane-enclosed lumen intracellular vesicle ficolin-1-rich granule intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen intracellular organelle organelle lumen cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle blood microparticle tertiary granule lumen tertiary granule endocytic vesicle lumen endocytic vesicle
C	Membrane protein	-	-	cellular anatomical structure membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002338	Hemoglobin, alpha-type	Family
A	IPR002339	Hemoglobin, pi	Family
A	IPR009050	Globin-like superfamily	Homologous Superfamily
A	IPR012292	Globin/Protoglobin	Homologous Superfamily
A	IPR000971	Globin	Domain
A	IPR050056	Hemoglobin and related oxygen transporters	Family
B	IPR009050	Globin-like superfamily	Homologous Superfamily
B	IPR012292	Globin/Protoglobin	Homologous Superfamily
B	IPR000971	Globin	Domain
B	IPR050056	Hemoglobin and related oxygen transporters	Family
B	IPR002337	Hemoglobin, beta-type	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P69905	alpha thalassemia Heinz body anemia acquired polycythemia vera methemoglobinemia hemoglobin H disease polycythemia familial hemolytic anemia alpha thalassemia-intellectual disability syndrome type 1 carcinoma sarcomatoid carcinoma Mammary Neoplasms, Experimental type 2 diabetes mellitus cerebral infarction hemolytic anemia inborn carbohydrate metabolic disorder alpha thalassemia Heinz body anemia acquired polycythemia vera methemoglobinemia hemoglobin H disease polycythemia familial hemolytic anemia alpha thalassemia-intellectual disability syndrome type 1 carcinoma sarcomatoid carcinoma Mammary Neoplasms, Experimental type 2 diabetes mellitus cerebral infarction hemolytic anemia inborn carbohydrate metabolic disorder mammary neoplasms, animal thalassemia congenital anemia facioscapulohumeral muscular dystrophy familial polycythemia hydrops fetalis lung adenocarcinoma beta thalassemia sickle cell anemia Hb Bart's hydrops fetalis hemoglobin M disease maturity-onset diabetes of the young breast carcinoma undifferentiated carcinoma diabetes mellitus
B	Pharos: P68871	sickle cell anemia beta thalassemia dominant beta-thalassemia Heinz body anemia polycythemia methemoglobinemia alpha thalassemia echinococcosis acquired polycythemia vera malaria hemoglobin C disease Plasmodium falciparum malaria Cyanosis hemoglobin D disease congenital dyserythropoietic anemia sickle cell anemia beta thalassemia dominant beta-thalassemia Heinz body anemia polycythemia methemoglobinemia alpha thalassemia echinococcosis acquired polycythemia vera malaria hemoglobin C disease Plasmodium falciparum malaria Cyanosis hemoglobin D disease congenital dyserythropoietic anemia inherited hemoglobinopathy familial hemolytic anemia beta-thalassemia HBB/LCRB hemoglobin E disease hemoglobin E-beta-thalassemia syndrome juvenile dermatomyositis delta-beta-thalassemia lung adenocarcinoma lymphoplasmacytic lymphoma malignant ependymoma MALT lymphoma gastric cancer myopathy anemia atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia beta-thalassemia major hemoglobin M disease cerebrovascular disorder hereditary persistence of fetal hemoglobin sickle cell-hemoglobin E disease syndrome thalassemia minor large cell medulloblastoma diabetes mellitus lung cancer Duchenne muscular dystrophy malignant glioma medulloblastoma acute myeloid leukemia gastric carcinoma non-small cell lung carcinoma B-cell chronic lymphocytic leukemia pancreatic intraductal papillary-mucinous carcinoma periodontitis breast cancer hemolytic anemia hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome sickle cell-hemoglobin c disease syndrome thalassemia invasive ductal breast carcinoma tuberculosis limb-girdle muscular dystrophy lung carcinoma ductal breast carcinoma in situ malignant colon neoplasm exocrine pancreatic carcinoma malignant pancreatic neoplasm familial polycythemia atopic eczema head and neck cancer ovarian cancer hemoglobin C-beta-thalassemia syndrome pancreatic intraductal papillary-mucinous neoplasm beta-thalassemia intermedia breast carcinoma hepatocellular carcinoma congenital anemia hypophosphatemic bone disease sickle cell-hemoglobin d disease syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.