Chemical Component Summary | |
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Name | Nortriptyline |
Synonyms | 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine |
Identifiers | 3-(5,6-dihydrodibenzo[1,2-a:1',2'-e][7]annulen-11-ylidene)-N-methyl-propan-1-amine |
Formula | C19 H21 N |
Molecular Weight | 263.377 |
Type | NON-POLYMER |
Isomeric SMILES | CNCCC=C1c2ccccc2CCc3c1cccc3 |
InChI | InChI=1S/C19H21N/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19/h2-5,7-11,20H,6,12-14H2,1H3 |
InChIKey | PHVGLTMQBUFIQQ-UHFFFAOYSA-N |
Chemical Details | |
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Formal Charge | 0 |
Atom Count | 41 |
Chiral Atom Count | 0 |
Bond Count | 43 |
Aromatic Bond Count | 12 |
Drug Info: DrugBank
DrugBank ID | DB00540 |
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Name | Nortriptyline |
Groups | approved |
Description | Nortriptyline hydrochloride, the active metabolite of [amitriptyline], is a tricyclic antidepressant (TCA).[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881] |
Synonyms |
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Brand Names |
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Indication | Nortriptyline is indicated for the relief of the symptoms of major depressive disorder (MDD).[L11878] Some off-label uses for this drug include treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.[A191083,L11878] |
Categories |
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ATC-Code | N06AA10 |
CAS number | 72-69-5 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
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Sodium-dependent noradrenaline transporter | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRD... | unknown | inhibitor |
Sodium-dependent serotonin transporter | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAV... | unknown | inhibitor |
5-hydroxytryptamine receptor 2A | MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSE... | unknown | antagonist |
5-hydroxytryptamine receptor 1A | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCA... | unknown | antagonist |
Histamine H1 receptor | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLY... | unknown | antagonist |
View More |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
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Pharos | CHEMBL445 |
PubChem | 4543 |
ChEMBL | CHEMBL445 |
ChEBI | CHEBI:7640 |
CCDC/CSD | JINGIW01, JINGIW, TOQWAA |