4DY

(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide

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is present as a standalone ligand in 7 entries

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Chemical Component Summary
Name	(6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide
Synonyms	Capsaicin; 8-Methyl-N-vanillyl-trans-6-nonenamide; NGX-4010
Identifiers	(E)-N-[(3-methoxy-4-oxidanyl-phenyl)methyl]-8-methyl-non-6-enamide
Formula	C₁₈ H₂₇ N O₃
Molecular Weight	305.412
Type	NON-POLYMER
Isomeric SMILES	CC(C)/C=C/CCCCC(=O)NCc1ccc(c(c1)OC)O
InChI	InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey	YKPUWZUDDOIDPM-SOFGYWHQSA-N

Chemical Details
Formal Charge	0
Atom Count	49
Chiral Atom Count	0
Bond Count	49
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB06774
Name	Capsaicin
Groups	approved
Description	Capsaicin is most often used as a topical analgesic and exists in many formulations of cream, liquid, and patch preparations of various strengths; however, it may also be found in some dietary supplements. Capsaicin is a naturally-occurring botanical irritant in chili peppers, synthetically derived for pharmaceutical formulations. The most recent capsaicin FDA approval was Qutenza, an 8% capsaicin patch dermal-delivery system, indicated for neuropathic pain associated with post-herpetic neuralgia.
Synonyms	Capsaicina Isodecenoic acid vanillylamide (E)-8-Methyl-N-vanillyl-6-nonenamide trans-8-Methyl-N-vanillyl-6-nonenamide Capsaicin
Brand Names	Nufabrx Ankle Sock Capsaicin Regular Cream CVS Capsaicin arthritis pain relief EMU THERAPY Red Hot Pepper Pain Relief Cream Rocksauce Fire LexiCaps Medi-patch With Lidocaine Rx Aspercreme Warming Triple Action Arthritis BioMega Heat Pain Therapy Terocin Relyyt Satogesic Hot Soothee Patch Paraid Hot Capsicum ZENSEZONE Arthmed Temporary Pain Relief Cream Leader Capsaicin Pain Relief Cream beeRX Muscle and Joint Pain Relief QC Arthritis Pain Relief Campo pharma Muscle hot CareALL Arthritis and Muscle Captracin Dr. OH BALM NuDiclo SoluPak Capsodan Cream Kerasal NeuroCream Miracle Plus Neck and Shoulder Pain Relief Invisible Pain Menthozen Perform Atomic Heat Toplast Cool and Hot Menthol 1.25percent plus Capsaicin 0.025percent Frankie Avalons ZERO PAIN Original Formula Roll-On Maximum Strength PAIN RELIEVER Arthritis Extra Strength Roll-ON Lotion Capsaicin HP Arthritis Pain Relief Sinsinpas Hot Solstice Capsaicin Patch Hot Yunnan Baiyao Arthritis Pain Relief Penetrex(r) Arthritis Pain Relief SprayPain Away 1st Medxpatch With Lidocaine 4% Ziclopro RockSauce FIERY HOT PAIN RELIEF LidoPro MediRelief Hot Overtime Hot Pain Relieving NuDroxiPAK Renovo Littles All Natural Arthritic Pain Relief Coralite Pain Relief Nufabrx Lower Leg Sleeve XL/XXL Migryl Biofrequency Chip Jupiter Pain Patch Diclosiacin Revlex Arthritis Pain Relief Sure Result DSS Premium Pak Atomic Balm Zostrix Diabetic Joint and Arthritis Pain Relief Arthritis Pain Relief Weh-Weh Natural Pain relief oil MINTED LEAF Heat Therapy Roll-On with Capsaicin and CBD CopperFixx Astrapharm Chilli Brand Coralite Medicated Heat Extra Strength Pain Reliever Painazin CP Arth RX Topical Analgesic Satohap Cool and Hot Pads A2a Arthritis Topical Pain Relief Rx FlexxSonic Pain Relief Mentholatum Ironman WellPatch Warming Pain Relief Apanol Linimento Obrero NaproxenPax Pain Away Hempvana Ultra Strength Pain Relief Cream - Deep Heat Trans-D Fatazen Sweat Enhance Hot Oprava Capsaicin Mild Cream Nufabrx Wrist Sleeve PainBloc Pain Relief Roll On DicloHeal-60 Pain Relief WellPatch Capsaicin Pain Relief Medi-sulting Topical Pain Relief Zostrix Original Strength Tianhe Gutong Tiegao LBri Super Aloe Stop The Pain Capzasin HP Arthritis Pain Relief Awaye Family Care Arthritis Pain Relief SmartRx Gaba-V Kit Benejoint Megrix OTC Nufabrx Hand/Wrist Sleeve Doloracin Rx Xyphex Biofrequency Chip Dyninex Reme D Pain Relief Hot Patch Capsaicin Cream Offense Player Sports Pain Relieving Gel-Patch Menthol, Capsaicin Pallerix OTC BIOfrequency Chip Menthozen Hydrogel Neuritrx DFS 75mg DR/MS 25%/MENTH 6%/CAP 0.025% PAK Hot spot point relief Overtime-X DINGTAI PHARMATopical Analgesic Ultra Strength Pain Relief Arthritazin Pain Relieving Pallerix Capsaicin Cream 0.025% IRxAmigra Iclofenac CP Red Hot Anodynz Biofrequency Chip Fast Arthritis Aid Pain Relieving Hurt Blocker Pro Nufabrx Compression Sock Nufabrx Grey Polka Dot Sock Lido-RX 4.1 Nufabrx Foot/Ankle Sleeve Ultra Therapy Pain Relief AmeriPatch Frankie Avalons Zero Pain Roll On Reliaderm Hong Hoa Pain Relieving Capzix CareOne Arthritis Pain Relief Toplast Hot Capsaicin 0.025percent CMX Topical Pain Capsaicin Forte Cream Allevess LCDO. ORLANDO RIVERA ARTHRITIS Topical Analgesic NuDroxiPAK DSDR-50 Aspercreme Warming No Mess Astronic bB Medicated Pain Relieving Oil Nufabrx Medicine Infused Socks Releevia MC N-LABS SOLAR MAX Topical Analgesic Good Neighbor Pharmacy Capsaicin Nexalgia Nufabrx Ankle Sleeve Capzasin-P Creme - 0.025% Exoten-C Arthritazin Pain Relieving EZ Nufabrx Calf Sleeve Alivio Medicated Pain Flanax Liniment Unit Dose Display Medrox-Rx Medicated Pain Relief Hot Hot Spot Point Relief Medi-patch With Lidocaine AVON HeXashield Arthritis Pain Relief Cream Capsaisin FYZICAL SPORTS Pain Relief 2 MILD Remaxazon External Patch Ameri Patch Arthricare for Women Quick Drying Medi-derm / L With Lidocaine Rx Soothe Parche Leon Milagroso Kool Heat Pain Therapy Sinelee Medicated Compression Sock Zostrix Foot Pain Relief Maximum Strength Nopiate Topical Pain Relief CANNABIN PLUS Warming Pain Relief Moisturizing Glucosamine Brand Medrox Rezil Solaice 2-Count HEAT PATCHES Toplast Cool and Hot Menthol 4percent plus Capsaicin 0.025percent Transderm-iQ CapsFenac Pak Dr. Harveys Herbal Motion Pain Formula Therapy Pain Capsaicin 0.075 Percent IRxMyoRub Wellness Products VictoRx Joint Maintenance Compliance Kit Power Pain Relief Stick Hot Pain Relief Flexin Glacierix Parche Leon Milagroso Dual Action New Terocin Dolor-parche With Lidocaine-RX PainKoolers Topical Analgesic Patch Med O-3 Bio- Nuvira Patch Renovo Lido5 Better Nature Pain Relief BalmX Family Care Thera Flex Pain Eagle Capsinac Tianhe Gutong Tiegao (in Polyisobutylene Carrier) Topical Pain Relief FYZICAL SPORTS Pain Relief Nufabrx Lower Leg Sleeve Therapatch Warm Red hot Nuvira RETADOLOR Pain Relief Flex-OL Theragen HP Good Neighbor Pharmacy Arthritis Pain Relief Capzasin P Arthritis Pain Relief Arthritic Pain Relief Silvera Pain Relief Patch Synovium Pain Relieving Gel PainMD Max BioMega K2c External Analgesic Capsicum Patch Aflexeryl-MC BRONSON SOOTHE Pain Relief Alegenix Biofrequency Chip Capsaicin Heat Patches Pain Relief NuDroxiPAK M-15 Capsaicin Heat Coralite Topical Analgesic Capsaicin Heat Simanix DCH Arthritis Pain Relief Roll-On Melt Pain Away Blue Ice Pain Relieving Rugby Arthritis Pain Relieving Topical Analgesic PainKoolers CyclobenzaprinePax Complete hemp Neuriterx Emu Essentials Brand Pain Relieving Levatio Patch Capsaicin Pain Relief NuDroxiPAK DSDR-75 Cvs Capsaicin Diclovix CM Sure Relief SR Relief Ziks Arthritis Pain Relief Capsaicin Arthritis Pain Relief Cream NaproPax Mac Raging Kakapo Pain Relieve Tianhe Zhuifeng Gao DICLAREAL TOPICAL kit My Omega Heat Therapy Pure Relief Pennsaicin Capsaicin Neuriterx 0.05% Inavix Kapsin Wasabi Rub Medi-derm Topical Pain Relief Diclofex DC Alivio FourPainRX Flexipak Miracle Plus Overnight Pain Relieving Zang Hong Hua Pain Relieving Rematex Rocksauce Ice Omega 3 Heat Therapy Rub A535 Capsaicin Diclosaicin PainBloc24 Dr Iyers MyoRub Offense Player Arthritis Pain Sherman and Clark Pain Relieving Menthocin Patch with Lidocaine - Strong Fors Pain Relief Dusel Warm Arthritis Dead Sea Salt Therapy Toplast Cool and Hot Menthol 5percent plus Capsaicin 0.025percent Capzasin No Mess Applicator Pain Relieving Menthacin - Cream Zostrix Joint and Arthritis Pain Relief BIO-MEGA Heat Therapy Theragen NuDiclo TabPak Capment NuDroxicin pain relief Roll-On Kanjo Natural Pain relief oil Kentwool SensationWool with Nufabrx Parche Leon Aleveer Patch Menthol 4.5% Capsaicin 0.0225% Assured Pain Relief Hot Menthol Sinsinpas Hot Large Antiphlogistine Rub A-535 Capsaicin Liquid LaboFlex Cool and Hot Menthol 1.25 percent Capsaicin 0.025 percent Mendex Compression Sock Walgreens Capsaicin Hot Ultracin Megrix Mega Patch MenCaps Zostrix Hp LivRelief Pain Relief Assured Pain Relief Hot Patch InstaSoothe Pain Relief Medicated Heat True Pain Relief Plus Capsaicin Topical Analgesic VANTELIN HOT PAIN RELIEVING Gel Patch Large Pain Relief Cream Extra Strength Antiphlogistine Rub A-535 Capsaicin Gel 1st Medxpatch With Lidocaine 4%-rx Equi-block Dt Formula LaBella Linimento Obrero Astrapharm Chilli Brand External Medicated Sure Result SR Relief LABOFLEX Cool and Hot Menthol 1.25 percent Capsaicin 0.025 percent CMC Pain Relieving Ageranium Patch Equate Capsaicin Pain Relieving Arthricare for Women Extra Moisturizing Cannavera Pain Relief Zostrix Hot and Cold Therapy System Coralite Muscle and Joint Pain Relief Kapzin DC MedWorx Arthritis Pain Reliever Qutenza Terphouse Migryl Diclopak Overtime-hmp Capxib Capsiderm Rugby Capsaicin External Analgesic Corisin Arthritis Pain Relief NuDroxiPAK N-500 Capsaicin External Analgesic Qroxin Patch Trubrexa Fesi Capzasin Quick Relief Bioaches Born Again Super Pain Relieving Lotion Moor Balm - Crm Lidopro Preferred Plus Arthritis Cream Australian Dream Power 4 Muscle and Joint Pain Relief Cream CVS Medicated Heat 1 ct Menthocin Patch with Lidocaine VANTELIN HOT PAIN RELIEVING Gel Patch HURT BLOCKER PRO Pain Relief Nufabrx Medicine Infused Ankle Sleeve NobleAid CapsAid Rite Aid Capsicum Hot AthletesGel Nufabrx Knee Sleeve SumaChip Menthozen Hydrogel Patch Pure Relief Penetrating Pain Relief Dr.'s Cream Arthmed Topical Analgesic Capsaicin 0.1 Percent Meijer Capsaicin Adazin Overtime-HMP Rugby Capsaicin Cream Anodynz Aspercreme Warming Patch Genorthix Pain Relieving Roll On Nufabrx Diabetic Sock Pain Relief Patch Rock Sauce MaC Patch Ultimate Topical Pain Relief Patch Douleurin Topical Pain Relief Xoten-C Minted Leaf Heat Therapy Relief Roll-On AnodyneRx FYZICAL SPORTS Pain Relief 1-COOL Screamin Hot Toast Bio-Sorb Outdoor Hands CVS Roll-On Pain Relieving Roll-On Ziclocin Capsaicin No-Fuss Applicator Limencin Earths Care Arthritis VitaCin Walgreens Arthritis Pain Relief Capsaicin Analgesic Dr Demand Relief Pain Relief Arth Arrest Dendracin Neurodendraxcin Capsaicin Heat Patches Back and Large Areas Dfs 1.5%/ms 25%/menth 6%/cap 0.025% Pak Gellert Joint Care Arthricare for Women Multi-action Medi-derm Rx LONOL Forte Gel Wellness Products J-FLEX Medi-derm / L With Lidocaine MINTED LEAF Heat Therapy Relief Roll On Rotex NuDroxicin Omega 3 Nufabrx Back Wrap NuDroxiPAK E-400 Nufabrx Lower Leg Sleeve XS/S Zostrix Foot Pain Relief KASEHA Pain Relieving Gel Good Neighbor Capsaicin Heat Patch for Back Pure Pain Relief PainKoolers Topical Analgesic Kessler Family Wellness Neuvaxin Patch Zostrix High Potency Foot Pain Relief Transanosil Nufabrx Lower Leg Sleeve M/L Muscular Balm Releevia Capsimide Castiva Warming Heet Liniment Liq PureKana Transderm-IQ FlexePax Arthur Itis Cream NuDroxiPAK I-800 Neurodexx Flanax Chill Pain Away Coralite Pain Relief Hot CVS Capsaicin Kapsin External Analgesic Capsaicin Hot Patches Leader Capsaicin Better Nature Pain Relief Cream Flanax Liniment Guardania Pain Nufabrx Arm Sleeve Nufabrx Neck Wrap Menthozen Cream Doloracin/l Rx With Lidocaine Soothanol X2 BLUE SPRING Foot and Leg Comfort Cream with Pain Relief Menthacin Lotion Reliever Cajun Hot Ice Muscle and Joint Pain Rub
Indication	The capsaicin 8% patch is indicated in the treatment of neuropathic pain associated with post-herpetic neuralgia. There are multiple topical capsaicin formulations available, including creams and solutions, indicated for temporary analgesia in muscle and join pain as well as neuropathic pain.
Categories	Alkaloids Alkenes Amides Analgesics Anesthetics Anesthetics, Local Antipruritics Basic Lotions and Liniments Benzene Derivatives Capsaicin and Similar Agents Cholinesterase Inhibitors Cytochrome P-450 CYP1A2 Inducers Cytochrome P-450 CYP1A2 Inducers (strength unknown) Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2E1 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dermatologicals Lipids Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates Peripheral Nervous System Agents Phenols Polyunsaturated Alkamides Sensory System Agents Solanaceous Alkaloids Topical Products for Joint and Muscular Pain TRPV1 Channel Agonists
ATC-Code	M02AB01 N01BX04
CAS number	404-86-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown	agonist,regulator
Prohibitin-2	MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAI...	unknown
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	inhibitor
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Myeloperoxidase	MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAA...	unknown	inhibitor
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate,inducer
Cytochrome P450 2E1	MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL...	unknown	substrate
Amine oxidase [flavin-containing] A	MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGG...	unknown	inhibitor
Dopamine beta-hydroxylase	MPALSRWASLPGPSMREAAFMYSTAVAIFLVILVAALQGSAPRESPLPYH...	unknown	inhibitor
Glutamine synthetase	MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSE...	unknown	inducer
Cholinesterase	MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFG...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682