6T0

1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine

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is present as a standalone ligand in 2 entries

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Chemical Component Summary
Name	1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
Identifiers	1-(2-methylpropyl)imidazo[4,5-c]quinolin-4-amine
Formula	C₁₄ H₁₆ N₄
Molecular Weight	240.304
Type	NON-POLYMER
Isomeric SMILES	CC(C)Cn1cnc2c1c3ccccc3nc2N
InChI	InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChIKey	DOUYETYNHWVLEO-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	34
Chiral Atom Count	0
Bond Count	36
Aromatic Bond Count	15

Drug Info: DrugBank

DrugBank ID	DB00724
Name	Imiquimod
Groups	investigational approved
Description	Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma.
Synonyms	Imiquimod 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine Imiquimodum
Brand Names	Aldara Taro-imiquimod Imiquimod 5% / Tretinoin 0.025% Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Niacinamide 2% Truemed Group LLC Zyclara Imiquimod Taro-imiquimod Pump Aldara P Vyloma Imiquimod 5% / Salicylic Acid 30% / Tretinoin 0.1% Imiquimod 5% / Niacinamide 4% Imiquimod 5% / Levocetirizine Dihydrochloride 1% / Tretinoin 0.05% Apo-imiquimod
Indication	For the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above.
Categories	Adjuvants, Immunologic Aminoquinolines Antineoplastic Agents Cancer immunotherapy Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Substrates Dermatologicals Heterocyclic Compounds, Fused-Ring Immune Response Modifiers Immunologic Factors Immunomodulatory Agents Immunosuppressive Agents Immunotherapy Increased Cytokine Activity Increased Cytokine Production Interferon Inducers Misc. Skin and Mucous Membrane Agents Quinolines Toll-Like Receptor Agonists
ATC-Code	D06BB10
CAS number	99011-02-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Toll-like receptor 7	MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVD...	unknown	agonist
Toll-like receptor 8	MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECS...	unknown	agonist
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682