Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L12885] Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885]
Synonyms
Risperidona
Rispéridone
Risperidone
Risperidone tartrate
Risperidonum
Brand Names
Risperdal
Okedi
Truemed Group LLC
PHL-risperidone
Jamp-risperidone
Nu-risperidone
Risperidone
Pro-risperidone
Ran-risperidone
Dom-risperidone
Mylan-risperidone ODT
Risperidone - 2
Risperidone - 0.25
Ipg-risperidone
Q-risperidone
Uzedy
Risperdal Consta
Risperidone M-TAB
Risperdal M-tab
Risperidone - 1
Act Risperidone
Taro-risperidone
Teva-risperidone
Dom-risperidone ODT
Risvan
PMS-risperidone
Sandoz Risperidone
Mint-risperidon
Risperidone - 0.5
Mylan-risperidone
Ava-risperidone
PHL-risperidone ODT
Perseris
Ag-risperidone
Riva-risperidone
Mar-risperidone
Risperidone - 3
PMS-risperidone ODT
Risperdal Oral Solution
Risperidone Tablets
Rykindo extended-release microspheres
Apo-risperidone
Risperidone - 4
Ratio-risperidone
Indication
Risperidone is indicated for the treatment of schizophrenia [L12885,L44692,L46297] and irritability associated with autistic disorder.[L12885] It is also indicated as monotherapy, or adjunctly with lithium or valproic acid, for the treatment of acute mania or mixed episodes associated with bipolar I disorder.[L12885,L44692] Risperidone is additionally indicated in Canada for the short-term symptomatic management of aggression or psychotic symptoms in patients with severe dementia of the Alzheimer type unresponsive to nonpharmacological approaches.[L12906] Risperidone is also used off-label for a number of conditions including as an adjunct to antidepressants in treatment-resistant depression.[A177226]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682