8XI

Cefaclor

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is present as a standalone ligand in 1 entries

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Chemical Component Summary
Name	Cefaclor
Synonyms	(6R,7R)-7-[[(2R)-2-azanyl-2-phenyl-ethanoyl]amino]-3-chloranyl-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Identifiers	(6~{R},7~{R})-7-[[(2~{R})-2-azanyl-2-phenyl-ethanoyl]amino]-3-chloranyl-8-oxidanylidene-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Formula	C₁₅ H₁₄ Cl N₃ O₄ S
Molecular Weight	367.807
Type	NON-POLYMER
Isomeric SMILES	c1ccc(cc1)[C@H](C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)Cl)C(=O)O)N
InChI	InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
InChIKey	QYIYFLOTGYLRGG-GPCCPHFNSA-N

Chemical Details
Formal Charge	0
Atom Count	38
Chiral Atom Count	3
Bond Count	40
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00833
Name	Cefaclor
Groups	approved
Description	Semisynthetic, broad-spectrum antibiotic derivative of cephalexin.
Synonyms	Cefaclor CCL Cefaclorum Céfeaclor Cefaclor monohydrate Céfaclor Cephaclor 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid Cefaclor anhydrous
Brand Names	PMS-cefaclor 250 - Pws 50mg/ml PMS-cefaclor 125 - Pws 25mg/ml PMS-cefaclor 375 B.I.D. Cefaclor Suspension Cefaclor-125 Cefaclor-250 Dom-cefaclor 125 - Sus 25mg/ml Cefaclor-500 Cefaclor Nu-cefaclor Dom-cefaclor 250-sus 50mg/ml PMS-cefaclor Apo-cefaclor Cefaclor-375 Ceclor Dom-cefaclor 375 B.I.D. Novo-cefaclor Nu-cefaclor Capsules 250mg Cefaclor Capsules
Indication	For the treatment of certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.
Categories	Amides Anti-Bacterial Agents Anti-Infective Agents Antibacterials for Systemic Use Antiinfectives for Systemic Use beta-Lactams BSEP/ABCB11 Substrates Cephalosporins Drugs that are Mainly Renally Excreted Heterocyclic Compounds, Fused-Ring Lactams Nephrotoxic agents OAT3/SLC22A8 Inhibitors OAT3/SLC22A8 Substrates Second-Generation Cephalosporins Sulfur Compounds Thiazines
ATC-Code	J01DC04
CAS number	53994-73-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Penicillin-binding protein 3	MKKIFLTLLTVSLLGGASTAVAQDFTIAAKHAIAVEANTGKILYEKDATQ...	unknown	inhibitor
Penicillin-binding protein 1A	MTERKREHKDRKQNKNSPKNQSKVTKFLKWFFIGILLLGITAVTVVGIYV...	unknown	inhibitor
Myeloperoxidase	MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAA...	unknown	inducer
Solute carrier family 15 member 1	MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDN...	unknown	inhibitor
Solute carrier family 15 member 2	MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIV...	unknown	inhibitor
Solute carrier family 22 member 8	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate,inhibitor
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682