A80
4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid
Find entries where: A80
is present as a standalone ligand in 2 entries
Chemical Component Summary | |
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Name | 4-[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbamoyl]benzoic acid |
Identifiers | 4-[(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid |
Formula | C22 H25 N O3 |
Molecular Weight | 351.439 |
Type | NON-POLYMER |
Isomeric SMILES | CC1(CCC(c2c1ccc(c2)NC(=O)c3ccc(cc3)C(=O)O)(C)C)C |
InChI | InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26) |
InChIKey | MUTNCGKQJGXKEM-UHFFFAOYSA-N |
Chemical Details | |
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Formal Charge | 0 |
Atom Count | 51 |
Chiral Atom Count | 0 |
Bond Count | 53 |
Aromatic Bond Count | 12 |
Drug Info: DrugBank
DrugBank ID | DB04942 |
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Name | Tamibarotene |
Groups | investigational |
Description | Tamibarotene is a novel synthetic retinoid for acute promyelocytic leukaemia (APL). Tamibarotene is currently approved in Japan for treatment of recurrent APL, and is undergoing clinical trials in the United States. |
Synonyms |
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Indication | Investigated for use/treatment in leukemia (unspecified). |
Categories |
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CAS number | 94497-51-5 |
Drug Targets
Name | Target Sequence | Pharmacological Action | Actions |
---|---|---|---|
Retinoic acid receptor alpha | MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPV... | unknown | agonist |
Retinoic acid receptor beta | MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPP... | unknown | agonist |
Cellular retinoic acid-binding protein 1 | MPNFAGTWKMRSSENFDELLKALGVNAMLRKVAVAAASKPHVEIRQDGDQ... | unknown |
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
Related Resource References
Resource Name | Reference |
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Pharos | CHEMBL25202 |
PubChem | 108143 |
ChEMBL | CHEMBL25202 |
ChEBI | CHEBI:32181 |