Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans.[T716] Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection.[T716] The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999.[L9863] According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a condition that interferes with lung development and may eventually cause asthma or early onset emphysema in those born prematurely.[A187694] Caffeine is beneficial in preventing and treating apnea and bronchopulmonary dysplasia in newborns, improving the quality of life of premature infants.[T716]
Synonyms
Methyltheobromine
1,3,7-trimethyl-2,6-dioxopurine
Theine
Anhydrous caffeine
Guaranine
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
1-methyltheobromine
Caféine
Teína
Caffeinum
Coffeinum
Cafeína
Coffein
Koffein
1,3,7-trimethylpurine-2,6-dione
7-methyltheophylline
Mateína
Caffeine
1,3,7-trimethylxanthine
Caffeine citrate
Thein
Brand Names
Pain Aid ESF
Tylenol No.1 Forte Caplets
Health Mart Migraine Relief
Care One migraine relief
Calmine Tab
Migraine Relief
A & C Tablets With Codeine 15mg
Goodys Cool Orange
Anacin Extra Strength Tablet
Complete Menstrual Relief
Ac and C Tab 1/8gr
Unishield Back Pain Off
Dihydrocodeine Bitartrate, Acetaminophen and Caffeine
Ana-dent
Medi First Plus Pain Ache
Atasol 15
Adults Acetaminophen and Caffeine Pain Reliever Fever Reducer
Goodys Migraine Relief
Excedrin Extra Strength Caplets
Atasol 30
Acetaminophen 500 Mg With 15 Mg Caffeine and 8 Mg Codeine Phosphate
Alert Aid
Ergotamine Tartrate and Caffeine
Back and Body Extra Strength
Fioricet with Codeine
BC Cherry
Menstrual Relief Extra Strength
Kirkland Signature Migraine Headache Relief
Family Wellness Migraine
Headache Pain Reliever
Orbivan
Excedrin Mild Headache Caplets
Phrenilin
Alka-seltzer Morning Relief
Alka-Seltzer Hangover Relief
Thrulife Extra Strength Headache Relief
Good Neighbor Pharmacy Stay Awake
Goodys PM Pain Reliever
Excinol Migraine (Acetaminophen)
Acetaminophen,Caffeine and Pyrilamine Maleate
Gencebok
Sinugex 38
Antidol Tablets
Lil Drug Store Headache Relief Extra Strength
Bayer Back and Body Extra Strength
Migraine Formula
Basic Care Migraine Relief
Norgesic Tab
Triaminicin Colds & Flu Caplets
Butalbital, Aspirin, Caffeine, and Codeine Phosphate
Dg Health Migraine Relief
Pain Aid
Fiorinal Tab
Wigraine Tab
Madelon
Arco Pain Tab
Aerotab Pain Reliever
Extra Strength Headache, Circle K
Caffeine Citrate Injection USP
NoSnooze Circle K
Excedrin Tension Headache
Caffeine Maximum Strength
Dolex Fem
Dristan Capsules
Extra Strength Pain Aid
292 Tablets
Pronal - C1/2 Capsules
Stanback
Excedrin Migraine, TRAVEL BASIX
Migrafein FORTE
Zee Painaid Back Relief Formula
Caffeine Citrate Oral Solution USP
Diurex Ultimate
Drowz Away Maximum strength
Tylo Migraine (Acetaminophen)
Bi Electro Extra Strength
Herbopyrine Tab 325mg
Stay Awake Maximum Strength
Bayer Headache
Medi First Plus Pain Zapper
Acetaminophen, Caffeine and Codeine Phosphate Tablets
Acetylsalicylic Acid, Caffeine and 8 Mg Codeine Phosphate
Anacin Extra Strength Caplets
Trianal C½
Menstrual Complete
Extra Strength Tylenol Total Cough, Cold & Flu
Acetaminophen 500mg and Caffeine 65mg
Novo-gesic-C8
Acetaminophen, Caffeine & 8mg Codeine Phosphate
Dolomine 37
Extra Pain Relief Acetaminophen, Aspirin (NSAID) and Caffeine
Novominsyrup
Sunmark Tension Headache
Headache Relief Extra Strength
Buscapina
Pain Relief Maximum Strength
Butalbital, Aspirin and Caffeine
Esgic
Butalbital Acetaminophen and Caffeine
pain relief back and body EXTRA STRENGTH
Acetaminophen Ultra Relief Extra Strength
Trianal Tablet
Dg Health Headache Relief
JET ALERT Regular Strength
Butalbital, Acetaminophen and Caffeine with Codeine Phosphate
Formu Care pain reliever added strength
Excedrin Menstrual Complete
Cafcit
EXCEDRIN MIGRAINE acetaminophen, aspirin (nsaid) and caffeine
Wigraine Suppositories
Topcare Migraine Formula
Excedrin Migraine Geltabs
BioElectro Day
Rx Act headache formula added strength
Acetaminophen, Butalbital and Caffeine
Menstrual Complete Gelcaps
Unishield Pain Ache
Headache Relief
Fiorinal-C 1/2
Cafergot Pb Sup
Midol Complete
Teen Pms Relief Complete Caplets
Sunmark Migraine Relief
Cafergot Sup
Good Sense headache formula added strength
Sunmark stay awake
Exaprin-AC
Menstrual Relief Maximum Strength
Allertness Aid
Fiorinal-C 1/4
Valumeds Maximum Strength Stay Awake
Isometheptene Mucate, Caffeine, Acetaminophen
Diurex Ultra
Neo-Lubrina Fuerte
Headache Formula Added Strength
Foster and Thrive Migraine Relief
Tylenol With Codeine No. 2 - Tab
Pronal Tablets
First Aid Shot Therapy Pain relief
Scot-Tussin Original SF Multi-Symptom
Apo-acetaco #1
C-2 Buffered With Codeine
Dvorah
Xpect Pain Away Extra Strength
PMS-pharnal-C 1/4 Capsules
SohMed Pain Reliever
Headache Relief Added Strength
Ultra Headache Relief
Unishield Pain Zapper
Tylenol Advanced Headache
Alertness Aid Stay Awake
Awake Maximum Strength
Excedrin PM Triple Action Caplets and Excedrin Extra Strength Pain Reliever
Exdol-30
Backprin
Pain Reliever Extra Strength
Fiorinal
PhysiciansCare Extra Stregth Pain Reliever
Acetaminophen Compound Tablets With Codeine 8mg
First Aid Shot Therapy Hangover Relief
Acetaminophen Aspirin Caffeine
Good Sense Stay Awake
Citramon
Butalbital, Acetaminophen and Caffeine
Migergot
Vanatol S
Teva-lenoltec No. 1
Ache and Pain Relief to Go
C2 Buffered Tab
Extra Strength Midol
Teva-lenoltec No. 2
Destim - Tab 200mg
Pamprin Max Menstrual Pain Relief
Penzal Q
jet-Alert Maximum Strength Alertness Aid
Green Guard Pain and Ache Relief
Vanapain
Excedrin
Alertness Aid Maximum Strength
Alertness Aid
Extra Strength Pain Reliever
Acetaminophene Codeine Et Cafeine Fort
Anacin ES
Goodys Headache Relief Shot
Diurex WaterCaps
Megral Tabs
Pep-Back Peak Performance
SohMed Alertness Aid
Uricalm Intensive
Lil Drug Store NoSnooze
282 Mep Tab
Bayer Headache Relief
BioElectro Extra Strength Daytime Pain Relief
Acetaminophen Caffeine & 8mg Cod Phos Tab
217
MigraTen
Extra Strength Midol Relief
Wampole-acetaminophen/codeine/caffeine
Esgic-Plus
Added Strength Pain Reliever
Acetaminophen Aspirin and Caffeine
Extra Strength Pain Relief
Midol Regular
Goodys
Anacin
Extra Pain Reliever
Medique Pain Off
Acetaminophen, Caffeine & Codeine
Careone Stay Awake
Acetaminophen, Aspirin and Caffeine
dihydrocodeine bitartrate and aspirin and caffeine DC
Headache Relief to Go
GOODYS Hangover
Exdol 8 Tab
Pain Reliever 2
Emertabs Tab
Cafizetamol Forte
Equate Migraine Relief
New Hanbang Col Cap
GOODYS Extra Strength Headache Mixed Fruit Blast
Pain Reliever
Butalbital, Acetaminophen, Caffeine
Pain Reliever Plus
Caffeine 200 mg
Stay Alert Aid
Pain Free
Acetaminophen Headache Ultra Relief
Cafergot
Ergotamine Tartrate, Caffeine
Nervine Tab
Smart Sense migraine relief
Excedrin Extra Strength Geltabs
Healthy Accents headache relief added strength
Extra Strength Headache Relief
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate
7 Select Migraine Formula
Equaline headache formula added strength
692 Tab
Teen Midol Complete
A.C. & C 8mg Tab
Bayer Rapid Relief
Instantine - Tablets
Novo Ac and C 8mg Tab
Triatec Fort/strong Ultra Efficace/ultra Relief
999 GANMAOLING Cold
Healthy Accents migraine formula
Butalbital, aspirin, and caffeine
Acetaminophene Codeine Et Cafeine Caplets
Vtol LQ
Bc
Equaline migraine formula
Sed-max
Fiorinal with Codeine
Alert Aid Caffeine Tablets 175mg
Sunmark Headache Relief
Care One headache relief added strength
Walgreens Pain Relief Powder
Peyona
Norgesic
Basic Care Headache Relief
First Aid Shot Therapy Pain Relief
Pain Away Plus
282 Tab
Berkley and Jensen Migraine Formula
Caffeine and Sodium Benzoate
Pain Reliever Added Strength
Cold Remedy Gan Mao Ling
Maximum Strength Menstrual Complete
Powerbooster Original
Alert Alertness Aid
Asa and Caffeine
Novo-gesic C15
Topcare stay awake maximum strength
Pain Stoppers
Diurex Water Pills
Vanatol LQ
Green Guard Extra Strength Pain Relief
Exdol-15
NoDoz MAXIMUM STRENGTH ALERTNESS AID
A & C Tablets With Codeine 30mg
Acetaminophen 325 Mg Caffeine and Codeine
Sedalmex Pain Reliever
Exdol-8
Aspirin, Caffeine, and Dihydrocodeine Bitartrate
Tension Headache Relief
Goodys Extra Strength
Acetaminophen 325 C & C
Menstrual Complete Pain Relief
Caffeine Citrate
Norgesic Forte
Neo Tigol Tab
Only For HEADACHE
Walmart Pain Relief Powder
Cl Light
Lil Drug Store NoSnooz Maximum Strength
Leader migraine formula
Anacin AF
Corytab
Tylenol W Codeine No3 Tab
Topcare Headache Formula
Vanquish Digital Headache
Circle K Headache Relief Extra Strength
EXTRA STRENGTH Headache Relief geltabs
Trezix
Handy Solutions Headache Pain Relief
Panlor
Acetaminophen W Codeine Tab
Acet 3
Oradrine 2 Tab
Oradrine Tablets
Circle K Headache Relief
Only For FIRST AID MEDICINE
Anacin Tablet
EXCEDRIN Tension Headache
Acetaminophen 250mg Aspirin 250mg Caffeine 65mg
Anacin With Codeine Tab
Caffeine
Exdol 30tab
Medi First Pain Ache
Dolodol
Excedrin Extra Strength and Excedrin Tension Headache
Ru-21 Hangover Relief
Dg Health Headache Relief Added Strength
BC Arthritis
Indication
Caffeine is indicated for the short term treatment of apnea of prematurity in infants and off label for the prevention and treatment of bronchopulmonary dysplasia caused by premature birth.[T716,L9851] In addition, it is indicated in combination with sodium benzoate to treat respiratory depression resulting from an overdose with CNS depressant drugs.[L9899] Caffeine has a broad range of over the counter uses, and is found in energy supplements, athletic enhancement products, pain relief products, as well as cosmetic products.[T716,L9854,L9872]
Categories
Alkaloids
Anorexigenic Agents & Respiratory and CNS Stimulants
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682