CHU

N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide


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Chemical Component Summary

NameN-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide
SynonymsCH5126766
Identifiers3-[[3-fluoranyl-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxy-chromen-2-one
FormulaC21 H18 F N5 O5 S
Molecular Weight471.462
TypeNON-POLYMER
Isomeric SMILESCC1=C(C(=O)Oc2c1ccc(c2)Oc3ncccn3)Cc4ccnc(c4F)NS(=O)(=O)NC
InChIInChI=1S/C21H18FN5O5S/c1-12-15-5-4-14(31-21-25-7-3-8-26-21)11-17(15)32-20(28)16(12)10-13-6-9-24-19(18(13)22)27-33(29,30)23-2/h3-9,11,23H,10H2,1-2H3,(H,24,27)
InChIKeyLMMJFBMMJUMSJS-UHFFFAOYSA-N

Chemical Details

Formal Charge0
Atom Count51
Chiral Atom Count0
Bond Count54
Aromatic Bond Count18

Drug Info: DrugBank

DrugBank IDDB15254 
NameAvutometinib
Groups investigational
DescriptionAvutometinib (RO-5126766 free base) is under investigation in clinical trial NCT03875820 (Phase I Trial of VS-6063 and RO5126766.).
Synonyms
  • Sulfamide, N-(3-fluoro-4-((4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl)methyl)-2-pyridinyl)-N'-methyl-
  • N-(3-fluoro-4-((4-methyl-2-oxo-7-((pyrimidin-2-yl)oxy)-2H-1-benzopyran-3-yl)methyl)pyridin-2-yl)-N'-methylsulfuric diamide
  • Avutometinib
  • RO-5126766 free base
Categories
  • Benzopyrans
  • Heterocyclic Compounds, Fused-Ring
  • Protein Kinase Inhibitors
  • Pyrans
CAS number946128-88-7

Related Resource References

Resource NameReference
Pharos CHEMBL3264002
PubChem 16719221
ChEMBL CHEMBL3264002
ChEBI CHEBI:78825