CLU

2,6-DICHLORO-N-IMIDAZOLIDIN-2-YLIDENEANILINE

Find entries where: CLU

is present as a standalone ligand in 2 entries

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Chemical Component Summary
Name	2,6-DICHLORO-N-IMIDAZOLIDIN-2-YLIDENEANILINE
Synonyms	CLONIDINE
Identifiers	N-(2,6-dichlorophenyl)imidazolidin-2-imine
Formula	C₉ H₉ Cl₂ N₃
Molecular Weight	230.094
Type	NON-POLYMER
Isomeric SMILES	c1cc(c(c(c1)Cl)N=C2NCCN2)Cl
InChI	InChI=1S/C9H9Cl2N3/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9/h1-3H,4-5H2,(H2,12,13,14)
InChIKey	GJSURZIOUXUGAL-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	23
Chiral Atom Count	0
Bond Count	24
Aromatic Bond Count	6

Drug Info: DrugBank

DrugBank ID	DB00575
Name	Clonidine
Groups	approved
Description	Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Synonyms	Clonidinum Clonidina 2-((2,6-Dichlorophenyl)imino)imidazolidine Clonidine Chlofazoline Clonidine hydrochloride 2,6-Dichloro-N-2-imidazolidinylidenebenzenamine Clonidin
Brand Names	Ntp-clonidine Sandoz Clonidine Combipres 0.1/15 Tab Kapvay Nu-clonidine Tab 0.1mg Apo-clonidine Tab 0.1mg Clonidine hydrochloride Dom-clonidine Clonidine hydrochloride extended-release Mint-clonidine Clonidine transdermal system Duraclon Teva-clonidine Clonidine Hydrochloride Catapres-TTS-2 Jamp Clonidine Clonidine HYDROCHLORIDE Nexiclon Nexiclon XR Apo-clonidine Tab 0.2mg Clonidine Transdermal System USP, 0.3 mg/day Clonidine Hydrochloride Extended-Release Clorpres Clonidine Hci Dixarit Tab 0.025mg Catapres-TTS-3 Catapres Catapres-TTS Mar-clonidine Nu-clonidine Tab 0.2mg Clonidine Transdermal System USP, 0.1 mg/day Clonidine Transdermal System USP, 0.2 mg/day Apo-clonidine Catapres Tab 0.1mg Clonidine Clonidine HCl Tab 0.2mg Catapres-TTS-1 Catapres Tab 0.2mg Clonidine 0.1
Indication	Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications.[L7237,L7240] A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient.[L7243] An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.[L7246] Clonidine is also used for the diagnosis of pheochromocytoma,[A180565] treatment of nicotine dependance,[A180568] and opiate withdrawal.[A180571]
Categories	Adrenergic Agents Adrenergic Agonists Adrenergic alpha-1 Receptor Agonists Adrenergic alpha-2 Receptor Agonists Adrenergic alpha-Agonists Agents producing tachycardia Agents that produce hypertension Analgesics Anesthetics Anesthetics, General Antiadrenergic Agents, Centrally Acting Antiglaucoma Preparations and Miotics Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension Antimigraine Preparations Autonomic Agents Bradycardia-Causing Agents Cardiovascular Agents Central alpha-2 Adrenergic Agonist Central Alpha-agonists Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Substrates Hypotensive Agents Imidazoles Imidazoline Receptor Agonists Imidazolines Narrow Therapeutic Index Drugs Nervous System Neurotransmitter Agents Ophthalmologicals Peripheral Nervous System Agents Sensory Organs Sensory System Agents Sympatholytics Sympathomimetics in Glaucoma Therapy
ATC-Code	S01EA04 C02LC01 C02AC01 N02CX02 C02LC51
CAS number	4205-90-7

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Alpha-2B adrenergic receptor	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLF...	unknown	agonist
Alpha-2C adrenergic receptor	MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGA...	unknown	agonist
Alpha-2A adrenergic receptor	MGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGLLMLLTVFG...	unknown	agonist
Alpha-1A adrenergic receptor	MVFLSGNASDSSNCTQPPAPVNISKAILLGVILGGLILFGVLGNILVILS...	unknown	agonist
Alpha-1B adrenergic receptor	MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGL...	unknown	agonist
Alpha-1D adrenergic receptor	MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGA...	unknown	agonist
Cytochrome P450 1A2	MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPL...	unknown	substrate
Cytochrome P450 3A4	MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNI...	unknown	substrate
Cytochrome P450 1A1	MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIG...	unknown	substrate
Cytochrome P450 3A5	MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNV...	unknown	substrate
Cytochrome P450 2D6	MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVD...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
Solute carrier family 22 member 3	MPSFDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYW...	unknown	inhibitor
Solute carrier family 22 member 5	MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRC...	unknown	inhibitor
Solute carrier family 22 member 4	MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRC...	unknown	inhibitor
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682