Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions.[L10701] Developed in 1957, it is structurally similar to other corticosteroids like [hydrocortisone] and [prednisolone].[A188724] Dexamethasone was granted FDA approval on 30 October 1958.[L10695] In a press release for the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial on 16 June 2020, dexamethasone was recommended for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone reduced deaths by approximately one third in patients requiring ventilation and by one fifth in those requiring oxygen.[L14318]
Neomycin and Polymyxin B Sulfates and Dexamethasone
DEXAMETHASONE Sodium Phosphate
Hemady
LoCort 7-Day
Npd
Apo-dexamethasone
Dexamethasone sodium phosphate
Dexamethasone Sodium Phosphate Inj USP 4mg/ml
Neomycin Sulfate, Polymyxin B Sulfate and Dexamethasone
Encor Dec Model 033-159 Imp 0.5mg/imp
Dexasone 0.5mg
Dexamethasone Sod Phosph Inj 10mg/ml USP
Dioptrol Ointment
Neodecadron Eye Ear Soln 0.1%
Netildex
Dexlido Kit
Mardex 25 Kit
Dexamethasone
Dexycu
Indication
Dexamethasone and [ciprofloxacin] otic suspension is indicated for bacterial infections with inflammation in acute otitis media and acute otitis externa.[L10698] Intramuscular and intravenous injections are indicated for a number of endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions.[L10701] Oral tablets are indicated for the treatment of multiple myeloma.[L10710] An intravitreal implant is indicated for some forms of macular edema and non-infectious posterior uveitis affecting the posterior of the eye.[L10719] Various ophthalmic formulations are indicated for inflammatory conditions of the eye.[L10704,L10707,L10713,L10716,L10722,L10725]
Categories
Adrenal Cortex Hormones
Adrenals
Agents Causing Muscle Toxicity
Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
