DHL

2-AMINO-ETHANETHIOL

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is present as a standalone ligand in 6 entries

as a non-polymer is covalently linked to polymer or other heterogen groups 8 entries

is present in a polymer sequence 1 entries

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Chemical Component Summary
Name	2-AMINO-ETHANETHIOL
Synonyms	2,3-DESHYDROLANTHIONINE
Identifiers	2-aminoethanethiol
Formula	C₂ H₇ N S
Molecular Weight	77.149
Type	L-PEPTIDE LINKING
Isomeric SMILES	C(CS)N
InChI	InChI=1S/C2H7NS/c3-1-2-4/h4H,1-3H2
InChIKey	UFULAYFCSOUIOV-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	11
Chiral Atom Count	0
Bond Count	10
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00847
Name	Cysteamine
Groups	approved investigational
Description	Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. A defect in cystinosin function is followed by cystine accumulation throughout the body, especially the eyes and kidneys.[A218721] Several preparations of cysteamine exist for the treatment of cystinosis manifestations, some in capsule form, and others in ophthalmic solution form.[L15606,L15616] In particular, cystine deposits on the eye can cause significant discomfort throughout the day and require frequent treatment with eye drops, typically every waking hour.[L15611] On August 25th 2020, the first ophthalmic solution for cystinosis requiring only 4 daily treatments was granted FDA approval.[L15606] Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis. Marketed by Recordati Rare Diseases Inc., CYSTADROPS® reduce the burden of multiple frequent medications normally administered to those with cystinosis.[L15601]
Synonyms	Mercaptaminum Cysteamine bitartrate 2-aminoethanethiol Mercaptamina Mercaptamine Cysteamine hydrochloride β-MEA Thioethanolamine Cysteamine beta-aminoethanethiol 2-amino-ethanethiol 2-amino-1-ethanethiol beta-Mercaptoethylamine MEA β-aminoethylthiol
Brand Names	Procysbi PROCYSBI Delayed-release Cystadrops Cystaran Cystagon
Indication	The bitartrate salt of cysteamine is used for the oral treatment of nephropathic cystinosis and cystinuria in adults and children ≥6 years old.[L15616] The hydrochloride salt, used in eye drop preparations, is indicated for the treatment of corneal cystine crystal accumulation in patients with cystinosis.[L15601,L15606]
Categories	Alimentary Tract and Metabolism Amines Amino Acids and Derivatives Cystine Depleting Agents Cystine Disulfide Reduction EENT Drugs, Miscellaneous Ethylamines Mercaptoethylamines Ophthalmics Ophthalmologicals Other Miscellaneous Therapeutic Agents Sensory Organs Sulfhydryl Compounds Sulfur Compounds
ATC-Code	A16AA04 S01XA21
CAS number	60-23-1

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Cystine	-	unknown	cleavage
Neuropeptide Y receptor type 2	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQ...	unknown	other/unknown
Myeloperoxidase	MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAA...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682