EPA

5,8,11,14,17-EICOSAPENTAENOIC ACID

Find entries where: EPA

is present as a standalone ligand in 8 entries

Find related ligands:

Chemical Component Summary
Name	5,8,11,14,17-EICOSAPENTAENOIC ACID
Identifiers	(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
Formula	C₂₀ H₃₀ O₂
Molecular Weight	302.451
Type	NON-POLYMER
Isomeric SMILES	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)O
InChI	InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
InChIKey	JAZBEHYOTPTENJ-JLNKQSITSA-N

Chemical Details
Formal Charge	0
Atom Count	52
Chiral Atom Count	0
Bond Count	51
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00159
Name	Icosapent
Groups	approved nutraceutical
Description	Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Synonyms	Icosapentaenoic acid all-cis-icosa-5,8,11,14,17-pentaenoic acid all-cis-5,8,11,14,17-eicosapentaenoic acid Icosapentum (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate Icosapent Icosapento Timnodonic acid (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid 5,8,11,14,17-Icosapentaenoic acid (all-Z)-5,8,11,14,17-eicosapentaenoic acid cis-5,8,11,14,17-eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid EPA cis-delta(5,8,11,14,17)-Eicosapentaenoic acid Eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid 5,8,11,14,17-eicosapentaenoic acid all-cis-5,8,11,14,17-icosapentaenoic acid cis-5,8,11,14,17-EPA Icosapent sodium
Brand Names	Protect Cardio AF Virt-Care One Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Tricare Prenatal 2-part Daily Prenatal Vitamin System Tricare Prenatal Twist-off DHA Soft Quick Dissolve Premium Omega 3 UltimateCare ONE NF Ultra Omega 3 Omega-3 Iq Childrens Chewable Tricare Prenatal DHA One With Folate Virt-Bal DHA Plus WestGel DHA Taliment WesCap-C-DHA Dothelle DHA Herbalifeline Oveeza VITAFOL Gummies Zatean-Pn Plus Natelle One NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Nutri-Tab OB plus DHA PNV-Omega Folcaps Omega-3 Folcaps Care One Gesticare DHA Se-Tan DHA Taliva TriStart DHA CitraNatal Assure Cavan One Se-Plete DHA NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Animi-3 Reliven CitraNatal Essence Super Omega 3 Melittin Joint Soothing Ge Tricare Prenatal DHA One Rx Multivitamin BP Vit 3 CitraNatal DHA Docosavit Gel TL-Care DHA Tricare Prenatal DHA One Virt-C DHA Vp-pnv-dha natelle COMPLETE Virt-PN Plus Animi-3 with Vitamin D A2A Omega 3 A2A Omega-3 Prenate Essential Vp-CH-pnv
Indication	EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
Categories	Agents causing hyperkalemia Agents that produce hypertension Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Dietary Fats Dietary Fats, Unsaturated Dietary Supplements Eicosanoids Fats Fatty Acids Fatty Acids, Omega-3 Fatty Acids, Unsaturated Fish Oils Hypolipidemic Agents Lipids Nephrotoxic agents Non COX-2 selective NSAIDS Oils Supplements
CAS number	10417-94-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inhibitor
Peroxisome proliferator-activated receptor gamma	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL...	unknown	agonist,regulator
Peroxisome proliferator-activated receptor delta	MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSS...	unknown	agonist
Free fatty acid receptor 1	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGC...	unknown	agonist
Sodium/calcium exchanger 1	MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECT...	unknown	inhibitor
Fatty acid-binding protein, brain	MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKV...	unknown	agonist
Fatty acid desaturase 1	MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTR...	unknown	agonist
Long-chain-fatty-acid--CoA ligase 4	MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKP...	unknown	inducer
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown	inducer
Peroxisome proliferator-activated receptor alpha	MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFG...	unknown
Arachidonate 5-lipoxygenase	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
View More

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682