EPA

5,8,11,14,17-EICOSAPENTAENOIC ACID

Find entries where: EPA

is present as a standalone ligand in 8 entries

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Chemical Component Summary
Name	5,8,11,14,17-EICOSAPENTAENOIC ACID
Identifiers	(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
Formula	C₂₀ H₃₀ O₂
Molecular Weight	302.451
Type	NON-POLYMER
Isomeric SMILES	CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)O
InChI	InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
InChIKey	JAZBEHYOTPTENJ-JLNKQSITSA-N

Chemical Details
Formal Charge	0
Atom Count	52
Chiral Atom Count	0
Bond Count	51
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB00159
Name	Icosapent
Groups	approved nutraceutical
Description	Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conversion into the thromboxane-2 and prostaglandin-2 families.
Synonyms	Eicosapentaenoic acid cis-5,8,11,14,17-EPA Timnodonic acid (5Z,8Z,11Z,14Z,17Z)-5,8,11,14,17-eicosapentaenoic acid Icosapentum Icosapent sodium (all-Z)-5,8,11,14,17-eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Icosapentaenoic acid all-cis-5,8,11,14,17-eicosapentaenoic acid 5,8,11,14,17-eicosapentaenoic acid Icosapentaenoic acid 5,8,11,14,17-Icosapentaenoic acid cis-5,8,11,14,17-eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoic acid (5Z,8Z,11Z,14Z,17Z)-Eicosapentaenoate cis-delta(5,8,11,14,17)-Eicosapentaenoic acid EPA Icosapento all-cis-5,8,11,14,17-icosapentaenoic acid all-cis-icosa-5,8,11,14,17-pentaenoic acid Icosapent
Brand Names	Animi-3 with Vitamin D Tricare Prenatal DHA One Vp-CH-pnv Tricare Prenatal DHA One Rx Multivitamin Virt-PN Plus Pre-Tabs DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA Gesticare DHA Reliven Omega-3 Iq Childrens Chewable UltimateCare ONE NF Animi-3 TL-Care DHA natelle COMPLETE Oveeza Nutri-Tab OB plus DHA Taliment Se-Tan DHA WesCap-C-DHA Se-Plete DHA Natelle One Super Omega 3 Virt-C DHA Tricare Prenatal DHA One With Folate Virt-Bal DHA Plus A2A Omega 3 Zatean-Pn Plus Taliva CitraNatal Essence Docosavit Gel Folcaps Omega-3 Herbalifeline Melittin Joint Soothing Ge Virt-Care One Vp-pnv-dha A2A Omega-3 CitraNatal Assure Cavan One CitraNatal DHA PNV-Omega VITAFOL Gummies Premium Omega 3 NESTABS ABC Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA WestGel DHA NESTABS DHA Prenatal Multi-vitamin/Mineral Supplement with DHA/EPA BP Vit 3 TriStart DHA Tricare Prenatal Twist-off DHA Soft Quick Dissolve Ultra Omega 3 Tricare Prenatal 2-part Daily Prenatal Vitamin System Dothelle DHA Protect Cardio AF Folcaps Care One Prenate Essential
Indication	EPA can be used for lowering elevated triglycerides in those who are hyperglyceridemic. In addition, EPA may play a therapeutic role in patients with cystic fibrosis by reducing disease severity and may play a similar role in type 2 diabetics in slowing the progression of diabetic nephropathy.
Categories	Agents causing hyperkalemia Agents that produce hypertension Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Anti-Inflammatory Agents, Non-Steroidal (Non-Selective) Dietary Fats Dietary Fats, Unsaturated Dietary Supplements Eicosanoids Fats Fatty Acids Fatty Acids, Omega-3 Fatty Acids, Unsaturated Fish Oils Hypolipidemic Agents Lipids Nephrotoxic agents Non COX-2 selective NSAIDS Oils Supplements
CAS number	10417-94-4

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Prostaglandin G/H synthase 2	MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFY...	unknown	inhibitor
Prostaglandin G/H synthase 1	MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFG...	unknown	inhibitor
Peroxisome proliferator-activated receptor gamma	MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDL...	unknown	agonist,regulator
Peroxisome proliferator-activated receptor delta	MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSS...	unknown	agonist
Free fatty acid receptor 1	MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGC...	unknown	agonist
Sodium/calcium exchanger 1	MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECT...	unknown	inhibitor
Fatty acid-binding protein, brain	MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKV...	unknown	agonist
Fatty acid desaturase 1	MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTR...	unknown	agonist
Long-chain-fatty-acid--CoA ligase 4	MKLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKP...	unknown	inducer
Transient receptor potential cation channel subfamily V member 1	MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLF...	unknown	inducer
Peroxisome proliferator-activated receptor alpha	MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFG...	unknown
Arachidonate 5-lipoxygenase	MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGA...	unknown	substrate
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown	binder
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682