FLU

2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID

Find entries where: FLU

is present as a standalone ligand in 11 entries

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Chemical Component Summary
Name	2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID
Synonyms	FLUORESCEIN
Identifiers	2-(3-hydroxy-6-oxo-xanthen-9-yl)benzoic acid
Formula	C₂₀ H₁₂ O₅
Molecular Weight	332.306
Type	NON-POLYMER
Isomeric SMILES	c1ccc(c(c1)C2=C3C=CC(=O)C=C3Oc4c2ccc(c4)O)C(=O)O
InChI	InChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24/h1-10,21H,(H,23,24)
InChIKey	YKGGGCXBWXHKIZ-UHFFFAOYSA-N

Chemical Details
Formal Charge	0
Atom Count	37
Chiral Atom Count	0
Bond Count	40
Aromatic Bond Count	23

Drug Info: DrugBank

DrugBank ID	DB00693
Name	Fluorescein
Groups	approved
Description	A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
Synonyms	D and C Yellow No. 7 9-(o-carboxyphenyl)-6-hydroxy-3-isoxanthenone Fluoresceine D&C Yellow No. 7 9-(o-carboxyphenyl)-6-hydroxy-3H-xanthen-3-one Resorcinolphthalein Japan Yellow 201 C.I. Solvent Yellow 94 Yellow fluorescein Fluoresceina 3,6-fluorandiol 3',6'-dihydroxyfluoran Fluorescein sodium Fluoreszein Fluoresceína Solvent Yellow 94 Fluorescein
Brand Names	Altafluor Fluorescein Sodium & Benoxinate Hydrochloride Ophthalmic Solution, USP Ful-glo Odan-fluoracaine Bio Glo BioGlo Fluress Liq Oph Ak-fluor Funduscein 25% Inj Fluorescite Flurox Fluorescein Sodium and Proparacaine Hydrochloride Fluorets (fluorescein Ophthalmic Strips) Minims Fluorescein Sodium Diofluor Strips Flucaine Angiofluor Lite Fluorox Fluress Fluorets - Stp Oph 1mg GloStrips Dry Eye Test Odan-fluorets Odan-fluorescein Fluorescein Sodium Fluorescein Sodium and Benoxinate Hydrochloride Fluorescein Fluorescein Lite Minims Lidocaine and Fluorescein Fluorescite Inj 25% Angiofluor
Indication	For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
Categories	BSEP/ABCB11 Substrates Coloring Agents Colouring Agents Compounds used in a research, industrial, or household setting Contrast Media Diagnostic Agents Diagnostic Dye Diagnostic Uses of Chemicals Fluoresceins Fluorescent Dyes Heterocyclic Compounds, Fused-Ring Indicators and Reagents Laboratory Chemicals Luminescent Agents OAT1/SLC22A6 inhibitors OAT1/SLC22A6 Substrates OAT3/SLC22A8 Substrates Ocular Disorders Ophthalmologicals Other Diagnostics Sensory Organs Spiro Compounds Xanthenes
ATC-Code	S01JA01 S01JA51
CAS number	2321-07-5

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Ig kappa chain V-II region RPMI 6410	MRLPAQLLGLLMLWVPGSSGDVVMTQSPLSLPVTLGQPASISCRSSQSLV...	unknown	other
DNA	-	unknown	other
Solute carrier family 22 member 6	MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCR...	unknown	substrate,inhibitor
Bile salt export pump	MSDSVILRSIKKFGEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQL...	unknown	substrate
Multidrug resistance-associated protein 1	MALRGFCSADGSDPLWDWNVTWNTSNPDFTKCFQNTVLVWVPCFYLWACF...	unknown	substrate

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682