FPP

FARNESYL DIPHOSPHATE

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is present as a standalone ligand in 65 entries

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Chemical Component Summary
Name	FARNESYL DIPHOSPHATE
Identifiers	phosphono [(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl] hydrogen phosphate
Formula	C₁₅ H₂₈ O₇ P₂
Molecular Weight	382.326
Type	NON-POLYMER
Isomeric SMILES	CC(=CCC/C(=C/CC/C(=C/CO[P@@](=O)(O)OP(=O)(O)O)/C)/C)C
InChI	InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+
InChIKey	VWFJDQUYCIWHTN-YFVJMOTDSA-N

Chemical Details
Formal Charge	0
Atom Count	52
Chiral Atom Count	1
Bond Count	51
Aromatic Bond Count	0

Drug Info: DrugBank

DrugBank ID	DB07780
Name	Farnesyl diphosphate
Groups	experimental
Synonyms	(E,E)-farnesyl pyrophosphate (2E,6E)-farnesyl pyrophosphate (2E,6E)-farnesol diphosphate Farnesyl pyrophosphate all-trans-farnesyl pyrophosphate (2E,6E)-farnesyl diphosphate Farnesyl diphosphate 2-trans,6-trans-farnesyl diphosphate (all-E)-farnesyl diphosphate
Categories	Organophosphates Organophosphorus Compounds Potential QTc-Prolonging Agents QTc Prolonging Agents Terpenes
CAS number	13058-04-3

Drug Targets

Name	Target Sequence	Pharmacological Action
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASP...	unknown
Protein farnesyltransferase subunit beta	MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAK...	unknown
GTPase KRas	MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET...	unknown
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	MKIRIGHGFDVHKFGEPRPLILCGVEVPYETGLVAHSDGDVVLHAISDAI...	unknown
Farnesyl pyrophosphate synthase	MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCW...	unknown
Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	MMLSATQPLSEKLPAHGCRHVAIIMDGNGRWAKKQGKIRAFGHKAGAKSV...	unknown
Lantibiotic nisin-Z	MSTKDFNLDLVSVSKKDSGASPRITSISLCTPGCKTGALMGCNMKTATCN...	unknown
Geranylgeranyl pyrophosphate synthase	MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIII...	unknown
(2Z,6E)-farnesyl diphosphate synthase	MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAG...	unknown
Geranylgeranyl transferase type-2 subunit alpha	MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLE...	unknown
Geranylgeranyl transferase type-2 subunit beta	MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGI...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682